In-vitro evaluation of antiproliferative activity of Cymbopogon citratus (lemon grass) against lung cancer
Journal Title: International Journal of Life Science - Year 2018, Vol 6, Issue 4
Abstract
The present study describes the phytochemical and anticancer activity of Cymbopogon citratus (Lemon grass) extracts on lung cancer CALU6 cell line. The phytochemical analysis revealed that Cymbopogon citratus consists of alkaloids, tannins, terpenoids, saponins and flavanoids. The antiproliferative activity of C. citratus exhibited an IC50 value of 134.0µg/ml on lung cancer CALU6 cell line. The gene expression study was conducted on caspase 3, caspase 8 & β actin revealed that C. citratus was found to suppress the expression of Caspase-3 and Caspase-8 genes but is more effective in the treatment of lung cancer because of inhibition of cell proliferation occurred through Caspase-independent pathway.
Authors and Affiliations
Mallikarjunaiah Shanthala, Mahesh Pattabhiramaiah, Preety Maimom, Chaitra GS, Diwan Nupur
Keywords
Related Articles
- EP ID EP545747
- DOI -
- Views 75
- Downloads 0
In vitro antifungal activity of ketoconazole against clinical isolates of Candida and Cryptococcus spp.
The incidence of fungal infections has been rising over the past few decades contributing to morbidity and mortality. Antifungal activity of ketoconazole was evaluated against clinical isolates of Candida abicans, C. gui...
Medicinal plants of tribal traditional system from Guntur district, Andhra Pradesh, India
Objective: To enumerate the medicinal plants used by the tribals of Guntur district in their traditional system for the cure of various human ailments. Very few ethnobotanical studies are reported from Guntur district. M...
Studies and synthesis of new drugs formed with fluoroquinolones and metal ions
The present article is focused on studies carried on fluoroquinolone metal complexes, their generalized procedures for synthesis of novel fluoroquinolones metal complexes and their anti-microbial properties. Fluoroquinol...
Histology of Seminiferous tubule of rat affected by Sildenafil Citrate
Sildenafil citrate studied for its use in the male reproduction .The long term use of Sildenafil citrate has their effect on various target organs. The study and effect of Sildenafil citrate carried out their side effect...
Copper Nanoparticles using Onion (Allium cepa) Extract and their Application in Plant Growth
Rapidly expanding use of nanoparticles in every section of life necessitates finding their potential to increase food production to match with increasing population. This study was conducted in NTRC (Nano Technology Rese...