In-vitro evaluation of antiproliferative activity of Cymbopogon citratus (lemon grass) against lung cancer
Journal Title: International Journal of Life Science - Year 2018, Vol 6, Issue 4
Abstract
The present study describes the phytochemical and anticancer activity of Cymbopogon citratus (Lemon grass) extracts on lung cancer CALU6 cell line. The phytochemical analysis revealed that Cymbopogon citratus consists of alkaloids, tannins, terpenoids, saponins and flavanoids. The antiproliferative activity of C. citratus exhibited an IC50 value of 134.0µg/ml on lung cancer CALU6 cell line. The gene expression study was conducted on caspase 3, caspase 8 & β actin revealed that C. citratus was found to suppress the expression of Caspase-3 and Caspase-8 genes but is more effective in the treatment of lung cancer because of inhibition of cell proliferation occurred through Caspase-independent pathway.
Authors and Affiliations
Mallikarjunaiah Shanthala, Mahesh Pattabhiramaiah, Preety Maimom, Chaitra GS, Diwan Nupur
Keywords
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