In-vitro evaluation of antiproliferative activity of Cymbopogon citratus (lemon grass) against lung cancer

Journal Title: International Journal of Life Science - Year 2018, Vol 6, Issue 4

Abstract

The present study describes the phytochemical and anticancer activity of Cymbopogon citratus (Lemon grass) extracts on lung cancer CALU6 cell line. The phytochemical analysis revealed that Cymbopogon citratus consists of alkaloids, tannins, terpenoids, saponins and flavanoids. The antiproliferative activity of C. citratus exhibited an IC50 value of 134.0µg/ml on lung cancer CALU6 cell line. The gene expression study was conducted on caspase 3, caspase 8 & β actin revealed that C. citratus was found to suppress the expression of Caspase-3 and Caspase-8 genes but is more effective in the treatment of lung cancer because of inhibition of cell proliferation occurred through Caspase-independent pathway.

Authors and Affiliations

Mallikarjunaiah Shanthala, Mahesh Pattabhiramaiah, Preety Maimom, Chaitra GS, Diwan Nupur

Keywords

Related Articles

Lead nitrate induced histochemical alteration in the liver of freshwater fish Mystus bleekeri (Day)

The present investigation deals with the effect of treatment of Lead nitrate, on the histochemical components of liver from freshwater fish, Mystus bleekeri. This fish was exposed to the 1/5th of LC50 concentration of Le...

Biocontrol efficacy of selected mosquitocidal bacteria

Insect species represent the largest percentage of the world’s known species. They are undoubtedly the most adaptable life forms existing on the Earth. Less than 0.5 percentage of the total number of the known insect spe...

Production of vinegar from pineapple peels using Acetobacter species isolated from soil sample and its antibacterial activity

Fruit waste has become one of the main sources of municipal solid wastes, which have been an increasingly tough environmental issue. Vinegar is very important food preservative in food industry. The vinegar can be obtain...

Selective comparison of repellent activity with Contact toxicity of certain essential oils against different insect orders

Elletaria cardamom, Merremia vitifolia and Peperomia pellucida Essential oils were tested against insects of 6 orders viz. Coleoptera, Diptera, Hemiptera, Hymenoptera, Isoptera and Lepidoptera. And were found to be effec...

Histopathological Effects of the Cestode parasites on fishes from the Amravati region of Vidarbha (MS) India

The histopathological studies of infected and non-infected intestinal tissue of the host; with scolex attached to the epithelium of mucosa (villi), mature and gravid segments in lumen of intestine and among the villi. It...

Download PDF file
  • EP ID EP545747
  • DOI -
  • Views 76
  • Downloads 0

How To Cite

Mallikarjunaiah Shanthala, Mahesh Pattabhiramaiah, Preety Maimom, Chaitra GS, Diwan Nupur (2018). In-vitro evaluation of antiproliferative activity of Cymbopogon citratus (lemon grass) against lung cancer. International Journal of Life Science, 6(4), 895-904. https://europub.co.uk/articles/-A-545747