Abstract

Objective: To test the effect of benzimidazole-derived compound (compound BTP-Iso) on cultured adult Schistosoma mansoni and clean Biomphalaria alexandrina snails. Methods: Adult schistosomes were incubated at different concentrations of compound BTP-Iso to calculate mortality rate, LC90 and LC50, in addition, tegumental changes were recorded using SEM. Clean Biomphalaria alexandrina snails were also incubated with compound BTP-Iso at various concentrations to report snail mortality. Results: Compound BTP-Iso was found to possess potent antischistosomal activities on adult worms but no effect was recorded on snail host. At a concentration of 8 µg/mL, mortality rates were 45.8% and 81.0% after 48 h and 72 h incubation, respectively, while 100% mortality was recorded after 48 h incubation at 20.0 µg/mL and after 72 h incubation at 10.0 µg/mL, with LC50 and LC 90 of 6.1 µg/mL and 9.8 µg/mL, respectively. Morphological changes and tegumental alternation of treated worms suggested loss of the tegument and its vital functions. Conclusions: This study provided the evidence for the potential antischistosomal effect of compound BTP-Iso and its possible uses as an alternative chemotherapeutic agent for treatment of schistosomiasis.

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