In Vitro Studies of Antibacterial and Antifungal Wound Dressings Comprising H<sub>2</sub>TiO<sub>3</sub> and SiO<sub>2</sub> Nanoparticles
Journal Title: Polish Journal of Microbiology - Year 2015, Vol 64, Issue 2
Abstract
The incidence rate of the infected and complex wound is established approximately 40 000/1 million of the world’s adult population. The aim of this study was to assess the efficiency of three novel types of wound dressings comprising sodium chloride, metatitanic acid and silicon dioxide nanoparticles. The study design was to prove their antimicrobial properties against the microorganisms most commonly causing wound infection. The study evaluated the antimicrobial effect of tested dressings on referenced strains of bacteria (ATCC collection, Argenta, Poland) and strains of fungi species (our own collection of fungi cultured from the patients). The dressings were tested with both bacterial and fungal strains on solid media (Mueller-Hinton, Sobouraud, bioMerieux, France) in the standard method. The results confirmed the inhibition of growth of bacteria and revealed zones of inhibition for [i]Escherichia coli[/i], [i]Staphylococcus aureus[/i] and [i]Enterococcus faecalis[/i]. Significant zones of inhibition were established for [i]Staphylococcus aureus [/i]and for fungi species of the [i]Candida species[/i]. These results would be a crucial due to the fact of low availability of antifungal therapeutics for both systemic and topical usage. Moreover, current standard of antifungal treatment is associated with high costs and high toxicity in general. The preliminary results are very promising but further studies are necessitated. According to achieved results, tested dressings may contribute to develop the surgical armamentarium of complex wound management in the near future.
Authors and Affiliations
Lukasz Krokowicz, Hanna Tomczak, Adam Bobkiewicz, Jacek Mackiewicz, Ryszard Marciniak, Michal Drews, Tomasz Banasiewicz
Keywords
Related Articles
- EP ID EP81142
- DOI -
- Views 96
- Downloads 0
Comparison of Methods Used for the Diagnosis of Epstein-Barr Virus Infections in Children
The accurate diagnosis of Epstein-Barr virus (EBV) infections is important, as many other infectious agents or diseases can cause similar symptoms. In this study, sera of pediatric patients who were suspected to have an...
The Application of Impedance Microsensors for Real-Time Analysis of Pseudomonas aeruginosa Biofilm Formation
Biofilms formed by nosocomial pathogens represent a major threat to patients undergoing invasive procedures. As prophylaxis remains the most efficient anti-biofilm option, it is of paramount importance to develop di...
Identification of Lactobacillus delbrueckii and Streptococcus thermophilus Strains Present in Artisanal Raw Cow Milk Cheese Using Real-time PCR and Classic Plate Count Methods
The aim of this paper was to detect Lactobacillus delbrueckii and Streptococcus thermophilus using real-time quantitative PCR assay in 7-day ripening cheese produced from unpasteurised milk. Real-time quantitative PCR as...
Physiological Effects of Whey- and Milk-Based Probiotic Yogurt in Rats
In an in vitro experiment commercially available probiotic products were tested for the survival of bacteria under conditions of simulated human digestion either when used alone or mixed into yogurt. In the in vivo exper...
Deletion of from Streptococcus pyogenes. Results in Hypervirulence in a Mouse Model of Sepsis and is LuxS Independent
Group A Streptococcus (GAS) is a Gram-positive human pathogen that causes a variety of diseases ranging from pharyngitis to life-threatening streptococcal toxic shock syndrome. Recently, several global gene expression an...