In-vitro Studies of Food Interaction with Dihydroartemisinin – Piperaquine Antimalarial Tablet
Journal Title: Journal of Pharmaceutical Research International - Year 2017, Vol 18, Issue 1
Abstract
The study assessed molecular interactions between the actives in antimalarial dihydroartemisinin-piperaquine (DP) tablet and food components using Fourier transform infrared spectroscopy (FTIR). Soluble starch, lactose, albumin, sunflower oil and carbonated drinks were pelletized with powdered DP tablet simultaneously using potassium bromide (KBr) method and analyzed with essential FTIR (eFTlR) software. Dihydroartemisinin (DHA) and piperaquine (PQ) showed characteristic bond vibrations consistent with reference to literature values. Carbohydrates food components had no significant effect on the DHA and PQ characteristic vibrations. Albumin powder shifted the aromatic (C-H) stretching of PQ from 3009 to 3387 cm-1, and aliphatic (C-H) stretching at 2874 to 2935 cm-1. DHA (C-H) stretching at 3419 cm-1 was shifted to 3387 cm-1 on admixture with albumin without significant shift for endoperoxide link (i.e., 875 to 881 cm-1), (C=O) stretching (i.e.,1735 to 1743 cm-1) and (O-H) stretching (2926 to 2928 cm-1). Sunflower oil caused a shift of the DHA spectra feature for (C-H) stretching at 3419 to 3385 cm-1. Sunflower oil also shifted the aromatic (C-H) bending for PQ from 775 to 721 cm-1. Carbonated drink admixture with DP tablet significantly shifted all the spectra features of PQ and DHA. Albumin and carbonated drinks produced significant changes in the spectra features of the actives in DP. Ingestion of protein meals or carbonated drinks with DP tablet may affect the bioavailability of the actives.
Authors and Affiliations
Sunday O. Awofisayo, Chioma N. Igwe, Nkechinyerem A. Jonathan, Alphonsus I. Francis, Peter D. Ojobor
Keywords
Related Articles
- EP ID EP312885
- DOI 10.9734/JPRI/2017/28516
- Views 69
- Downloads 0
Dynamic Changes in Antioxidant Activity during Floral Development of Couroupita guianensis
Aims: To establish and optimize the in vitro antioxidant activity of methanolic extract of flower of C. guianensis at different developmental stages. Place and Duration of Study: Plant Physiology and Pharmacognosy Resea...
Three Triterpenoids from the Leaf Extract of Vitex doniana (Verbenaceae)
Three triterpeniods were isolated from the leaf extract of Vitex doniana (Verbenaceae). Their structures were established mainly by FTIR, FABMS, highresolution(1Dand 2D) spectroscopic and chemical analysis as 1α, 3β-dih...
Bioactive Phenylethanoids from the Seeds of Manilkara zapota
Aims: Discovering new lead compounds against cancer and bacterial infections is a crucial step to ensuring a sustainable global pipeline for new effective drugs. These study focuses on the isolation of secondary metaboli...
Comparative Phytochemical Screening and In vitro Evaluation of Biological Activities between Aqueous and Ethanolic Extract of Momordica charantia L. Fruits
Aims: The study was conducted to compare the presence of different phytochemicals and biological activities like cytotoxicity, anthelmintic activity, antioxidant and free radical scavenging activities between aqueous and...
Tetrapleura tetraptera Taub- Ethnopharmacology, Chemistry, Medicinal and Nutritional Values- A Review
Ethnopharmacological Relevance: Tetrapleura tetraptera Taub (Fabaceae-Mimosoideae) is a well-known tree growing widely in forest zones all over West Africa. It is used in wound-healing, diabetes mellitus, asthma, hyperte...