IN VITRO STUDIES ON THE EFFECT OF PROSOPIS CINERARIA ON THE MOTILITY AND ACETYLCHOLINESTERASE OF COTYLOPHORON COTYLOPHORUM
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2015, Vol 7, Issue 3
Abstract
Paramphistomosis caused by the paramphistome Cotylophoron cotylophorum constitute a major group of disease in domestic ruminants. Chemical control of helminths coupled with improved management has important worm control strategy throughout the world. However, increasing problems of development of resistance in helminths against anthelmintics have led to the proposal of screening of medicinal plants for their anthelmintic activity. In the present investigation, the anthelmintic efficacy of bark of Prosopis cineraria was assessed based on its effect on the motility and on the enzyme acetylcholinesterase (AChE) of Cotylophoron cotylophorum. The flukes were exposed to five different concentrations (1, 2, 3, 4 and 5%) of ethanol extract of bark of Prosopis cineraria (PcEE) for 2, 4 and 8 h. The motility response of the drug-treated parasites was quantitatively measured with the aid of Electronic Micromotility Meter (EMM). The electronic measurement of the motility of the drug-treated parasites clearly indicates the direct impact of the drugs on the motility of the parasite. Maximum level of inhibition of the motility response of the parasites was observed at 5% concentration after 8 h of exposure of PcEE. AChE was assessed. PcEE significantly inhibited the activity of AChE. As, AChE plays an important role in neurotransmission, inhibition of AChE results in muscular paralysis of parasites which loose its “biochemical hold-fast” and gets eliminated from the host. PcEE possesses a remarkable anthelmintic activity against C. cotylophorum. It may serve as an alternative for anthelmintic chemotherapeutic agents and could be used in a safe and eco friendly manner. However, this study warrants further in vivo studies for practical utility.
Authors and Affiliations
C. Manigandan, L. Veerakumari
Keywords
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