Abstract

In ancient India many herbal plant products were used for their medicinal values. Calotropis procera known as arka, madar, milkweed. It was used as antimicrobial, antifertility, anticancer, leprosy and antihelmintic. In the present study the ethanolic extract of the leaf was used to study for its spasmolytic activity. The study was carried out in rabbit jejunum by standard bioassay. The response of Calotropis procera was observed at different concentrations. The responses of drug as well in combination with serotonin were taken and degree of inhibition noted. It was found that the ethanolic extract of c.procera produced significant inhibition of serotonin activity. This clearly signifies that Calotropis procera has spasmolytic activity. The leaf extract of plant can be used as remedy for spasmodic pains.

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