In vitro Susceptibility Analysis of Escherichia coli Strains Isolated from Urinary Tract Infections to Fosfomycin, Nitrofurantoin and Ciprofloxacin
Journal Title: Mediterranean Journal of Infection, Microbes and Antimicrobials - Year 2015, Vol 4, Issue 1
Abstract
Introduction: Escherichia coli is the most commonly isolated microorganism from uncomplicated lower urinary tract infections (UTI). The occurrence of high ciprofloxacin resistance and production of extended spectrum beta-lactamase (ESBL) in E. coli isolates have led the researchers to investigate new treatment approaches. Materials and Methods: A total of 366 E. coli strains isolated from urine samples of patients with the diagnosis of UTI, who were referred to our laboratory from different departments at our hospital, were included in this study. Results: Ninety (24.6%) isolates were found to be ESBL-positive and 276 (75.4%) were ESBL-negative. The rates of susceptibility to fosfomycin, nitrofurantoin and ciprofloxacin in ESBL-positive and ESBL-negative E. coli strains were found to be 100% and 99.7%, 80% and 90.6%, and 40% and 80.8%, respectively. Conclusion: In conclusion, ciprofloxacin resistance was high and resistance to fosfomycin and nitrofurantoin was very low in E. coli. Therefore, we assume that fosfomycin and nitrofurantoin can be used as empiric therapy for uncomplicated UTI caused by E. coli.
Authors and Affiliations
Sevda SOYDAN, Gülkan KARADAĞ, Emel ÇALIŞKAN, Ebru KALE
Keywords
Related Articles
- EP ID EP689381
- DOI 10.4274/mjima.2015.3
- Views 132
- Downloads 0
Osteoarticular Involvement and Inadequate Treatment of Brucellosis are Related to Relapse
Introduction: The goal of treatment in brucellosis is to control symptoms to prevent the development of complications and relapse of infection. The aim of this study was to evaluate the risk factors for relapse in brucel...
New Antibiotics in the Therapy of Osteomyelitis
Osteomyelitis is probably the oldest known infection in the history of life. It can develop secondary to local tissue disruption, ischemia and associated chronic wounds or via hematogenous infection. Although it has been...
EDİTÖRYAL
No Abstract
Current Status in Middle East Respiratory Syndrome Coronavirus
Middle East respiratory syndrome coronavirus (MERS-CoV) which was first described in 2012, belongs to the CoV family. Coronaviruses may cause global outbreaks with high mortality. Although there is no definite evidence,...
When to Start Prophylaxis? A HIV-infected Patient Presenting with Upper Extremity Weakness
No Abstract