Abstract

There has been a rapid rise in multidrug-resistant uropathogenic organisms. A retrospective study was carried out in our Institution, which is a Tertiary Care Center in North India, to find out susceptibility of Escherichia coli (E. coli) and Enterococcus faecalis (E. faecalis) isolates to an older generation antibiotic fosfomycin. A total of 3270 isolates from urinary samples were tested. 1701 (52.02%) were E. coli and 500 (15.29%) Enterococcus faecalis isolates. 704 (41.39%) of E. coli were found to be extended spectrum β-lactamase (ESBL) producers and 183 (10.76%) metallo β-lactamase (MBL) producers. Out of 500 E. faecalis isolates, 247 (47.4%) were high-level aminoglycoside resistant (HLAR) and 5 (1%) vancomycin-resistant enterococci (VRE). On testing sensitivity to fosfomycin, 94.89% ESBL producing E. coli, 89.16% MBL producing E. coli, 97.17% HLAR and 80% VRE were found susceptible. Overall only 1.09% of E. Coli and 1.33% of Enterococcus faecalis isolates were fosfomycin resistant. From this study, we conclude that fosfomycin may be considered as a useful oral antibiotic for the treatment of urinary tract infections with drug-resistant E. coli and/or E. faecalis.

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