In Vivo Analgesic Potential in Swiss Albino Mice and in Vitro Thrombolytic and Membrane Stabilizing Activities of Methanolic Extract From Suaeda Maritima Whole Plant
Journal Title: Bagcilar Medical Bulletin - Year 2017, Vol 2, Issue 1
Abstract
Objective: Cold methanolic extract of Suaeda maritima have been considered to screen their biological properties such as analgesic, membrane stabilizing and thrombolytic activity. Although some investigations have previously been reported with this plant, the whole plant was not studied yet to date. In the present study we aimed to investigate in vivo and in vitro bioactivities of Suaeda maritima. Material and Methods: The pharmacological analgesic activity was studied by acetic acid induced writhing method in vivo in a mouse model. Membrane stabilizing activity was assessed by inhibition of haemolysis at hypotonic solution induced condition in vitro, and thrombolytic activity was evaluated by employing Streptokinase as standard in vitro. Results: Extract of Suaeda maritima at a dose of 500 mg/kg body weight showed most significant inhibition of writhing at a rate of 82.25% in mice. Among all the fractions, crude methanol extract (ME) showed maximum effect with a value of 61.01% inhibition of hemolysis at 10 mg/ml dose, when standard acetyl salicylic acid (0.10 mg/mL) revealed 66.37% inhibition of hemolysis. When clots were treated with 100 μl, moderate clot lysis activity observed with each of the test sample, however highest effect was found at 10 mg/ml dose (49.13%). Conclusion: The Suaeda maritima extract showed a remarkable analgesic effect on a mouse model and membrane stabilizing and trombolytic activities in vivo models. It may introduce a new dimension in human model in analgesic, membrane stabilizing and antitrombolytic activities.
Authors and Affiliations
Md. Mamunur Rashid, Md. Saddam Hussain, Md. Mamun Or Rashid, Md. Abdul Halim, Niloy Sen, Md. Shalahuddin Millat, Md. Al-Amin Sarker
Keywords
Related Articles
- EP ID EP50387
- DOI 10.5350/BMB20170306094829
- Views 224
- Downloads 0
Anesthesia Management in a Patient with Cystic Fibrosis (A Case Report)
Cystic fibrosis (CF) is a hereditary disease resulting from a chlorine channel defect with autosomal recessive transmission, a structural and functional disorder in the transport of chlorine (Cl) through the plasma membr...
Effect of Nasopharyngeal Irrigation on Early Eustachian Tube Functions in Patients Undergoing Adenoidectomy: A Clinical Prospective Study
Objective: The hypertrophic adenoid tissue can cause to eustachian tube dysfunction by mechanical or inflammatory effect both of which block the nasopharyngeal ostium of the eustachian tube. Adenoidectomy, with or withou...
Clinical Outcomes and Factors Affecting the Outcome of Decompressive Craniectomy: Analysis of 50 Cases
Objective: Decompressive craniectomy (DC) is used as the last-stage method in the treatment of increased intracranial pressure (ICP). However, clinical outcomes reported in the literature are contradictory. Methods: Med...
CYP2C19*1 and CYP2C19*2 Polymorphism in Turkish Patients Being Diagnosed with Stable Coronary Artery Disease and Using Clopidogrel
Objective: The CYP2C19*1 has an entirely normal activity allele whose clopidogrel metabolism is normal. CYP2C19*2 called as non-functional alleles. In this study, we aimed to establish the CYP2C19*1 and CYP2C19*2 genotyp...
Association of Cervical Screening Results with Colposcopic Findings
Objective: Cervical cancer is the fourth most common female cancer. In addition to early cancer diagnosis, the screening strategy of cervical cancer is based on early diagnosis of precancerous lesions [high-grade cervica...