IN-VIVO AND IN-VIRO MAST CELL STABLIZING ACTIVITY OF ETHYL ACETATE AND METHANOL EXTARCT OF TERMINALIA CHEBULA FRUITS: A THERAPEUTIC APPROACH FOR ASTHMA
Journal Title: International Journal of Pharmacognosy - Year 2016, Vol 3, Issue 6
Abstract
The present investigation deals with the In-vivo and In vitro mast cell stabilizing activity of fruits of Terminalia chebula ethyl acetate and methanol extracts at 500 mg/kg bodyweight. In egg albumin induced degranulation studies, Kitotifen as a standard was found to inhibit degranualtion to an extent of 80.12 %, where as ethyl acetate and methanolic extracts inhibited degaranulation to 58.98% and 44.56% respectively similarly in compound 48/80 induced mast cell degranulation inrats ethyl acetate and methanol extracts of Terminalia chebula and standard Kitotifen showed following percentage inhibition of degranulation of mast cell 40.28%, 51.19 % and 75.12 respectively. In in vivo study ethyl acetate and Methanolic extracts at the dose of 500 mg/kg bodyweight inhibited degranualation of mast cell to a extent of 46.5 % and 37.33% respectively.
Authors and Affiliations
Sweta Srivastava
Keywords
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