Abstract

Objective: To evaluate the in vivo anti-androgenic, antioxidant activity and anti-estrogenic activities of Eremomastax speciosa (E. speciosa) in order to find new method for fighting against chronic diseases such as cancer. Methods: Evaluations of antiandrogenic and antioxidant activities were carried out on male rate receiving simultaneous daily administration of testosterone and different doses of aqueous extract of E. speciosa, during a period of 10 d. The evaluation of antiestrogenic activity was carried out on mature ovariectomized female rats receiving simultaneous daily administration of estradiol and different doses of extract, for a week. Then reproductive organs were weighted, levels of prostatic acid phosphatase, superoxide dismutase and catalase as well as some hematologic parameters were measured. Results: The treatment significantly reduced (P<0.01 ) the weight of ventral prostate, penis, Cowper’s gland and the level of serum prostatic acid phosphatase; while a significant decrease (P<0.01) of the catalase activity was observed. A significant increase (P<0.05) in the lymphocyte number and significant decrease of monocyte (P<0.05) were noticed. The uterine relative weight were significantly reduced (P<0.01). Conclusions: Generally, these results denote the antiandrogenic, antiestrogenic and immunomodulatory potential of E. speciosa.

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