IN-VIVO ANTI-INFLAMMATORY ACTIVITIES OF ETHANOLIC ROOT EXTRACT OF BAUHINIA VARIEGATA LINN
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 8
Abstract
Objective: The objective of present study was to evaluate the anti-inflammatory activity of ethanolic extract of Bauhinia variegate root.Methods: In the present study BVEE at 200 and 400 mg/kg body weight was studied for anti-inflammatory activities in different animal models.. Anti- inflammatory activity was carried out by using carrageenan induced paw edema model and cotton pellet induced granuloma model in wistar rats.Results: The results shows that BVEE possess anti-inflammatory activity in acute as well as sub acute models of inflammation in rats. BVEE (200 and 400 mg/kg) showed significant (p <0.01) anti-inflammatory activity by reducing the paw edema volume in carrageenan-induced paw edema in rats in the late phase (2to4h)regulated by prostaglandins and leucotrienes and in cotton pellet induced granuloma model BVEE decreased dry weight of granuloma.Conclusion: The observed pharmacological activity may be due to presence of phytochemical compounds present in the extract like alkaloids, flavonoids, phenols, saponins and tannins.Â
Authors and Affiliations
Meena Prabha, Kamala Kannan, K. s. g. arul Kumaran, Dr. r. sambath Kumar
Keywords
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