Abstract

Objective: To evaluate antinociceptive and anti-inflammatory activities of Lippia alba (Mill.) N.E. Brown (Verbenaceae) leaves. Methods: Soxhlet extraction method was used to obtain extracts using petroleum ether extracts (PELA); chloroform extracts (CELA); ethanol extracts (EELA) and aqueous extract (AELA). Antinociceptive activity was assessed on rats by tail flick latency using tail immersion method and anti-inflammatory activity was estimated by carrageenan induced paw edema method. PELA, CELA and AELA at a dose of 500 mg /kg.b.wt. and EELA at a dose of 460 mg /kg.b.wt were administered orally. Result: Competing to control AELA was found to have a higher range of anti-nociceptive activity and showing maximum (79.66%) response at 60 min, where as CELA and EELA were found to have a maximum range of anti-inflammatory activity and CELA exhibit maximum (19.5%) response at 240 min. Conclusion: The results suggest that the extracts of Lippia alba possess ant-inociceptive and anti-inflammatory activities, and its help to authenticates the use of the plant in the traditional treatment of ailments associated with pain and inflammation.

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