In vivo anticancer activity of vanillin semicarbazone
Journal Title: Asian Pacific Journal of Tropical Biomedicine - Year 2012, Vol 2, Issue 6
Abstract
Objective To evaluate the anticancer activity of vanillin semicarbazone (VSC) against Ehrlich ascites carcinoma (EAC) cells in Swiss albino mice. Methods The compound VSC at three doses (5, 7.5 and 10 mg/kg i.p.) was administered into the intraperitoneal cavity of the EAC inoculated mice to observe its efficiency by studying the cell growth inhibition, reduction of tumour weight, enhancement of survival time as well as the changes in depleted hematological parameters. All such parameters were also studied with a known standard drug bleomycin at the dose of 0.3 mg/kg (i.p.). Results Among the doses studied, 10 mg/kg (i.p.) was found to be quite comparable in potency to that of bleomycin at the dose of 0.3 mg/kg (i.p.). The host toxic effects of VSC was found to be negligible. Conclusions It can be concluded that VSC can therefore be considered as potent anticancer agent.
Authors and Affiliations
Shaikh M MohsinAli, M Abul KalamAzad, Mele Jesmin, Shamim Ahsan, Jahan Ara Khanam, Sha M Shahan Shahriar
Keywords
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