In vivo Antimalarial Activity of Capparis tomentosa Lam. in Mice Infected with Plasmodium berghei
Journal Title: Journal of Ayurvedic and Herbal Medicine - Year 2019, Vol 5, Issue 2
Abstract
The present study was aimed to assess the antiplasmodial properties of crude extracts of Capparis tomentosa Lam. The plant materials were collected from their natural habitat and extracted using 80% methanol and non-polar solvents. A Plasmodium berghei, which is a parasite that infects mice, was kept up at the Aklilu Lemma Institute of Pathobiology laboratory and it was injected into experimental mice. The mice were given 1x107 parasites intraperitoneally for initial infection. The extracts were given through oral gavage daily for four days, since the day when infection was commenced. The negative control groups were given the equivalent amount of solvent (vehicle) used to suspend each dose of the extract. For the positive control groups, Chloroquine was given orally as a standard drug. Data obtained from the experiment was analyzed using one way ANOVA. The results indicated that the plant extracts exhibited significant antimalarial activities. Extracts from the plant extract exhibited significant antimalarial activities and prevented body weight loss (P<0.05) but did not prevent PCV reduction in dose dependent manner and mean survival time was not prolonged. The hydro-alcoholic extract of C. tomentosa was found to be the most active with a suppression of 78.2% at the dose of 1000 mg/kg. Therefore, the results indicated the potential use of the claimed medicinal plant for the treatment of malaria in primary health care.
Authors and Affiliations
Sibhatu Gebrehiwot, Murtse Giday, Berhanu Erko, Yalemtsehay Mekonnen
Keywords
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