IN-VIVO ANTIOXIDANT AND ANTIHYPERLIPIDEMIC ACTIVITY OF SYZYGIUM CERASOIDEUM EXTRACTS IN RATS
Journal Title: International Journal of Pharmaceutical Sciences and Research (IJPSR) - Year 2019, Vol 10, Issue 6
Abstract
Antioxidant and antihyperlipidemic activities of the extracts of Syzygium cerasoideum were investigated by studying their in-vivo effects on triton and cholesterol induced hyperlipidemia. Highest antioxidant activity was exhibited by methanolic extract followed by chloroform extract of S. cerasoideum. In triton induced hyperlipidemic model, the groups treated with the extracts of S. cerasoideum and pitavastatin demonstrated a significant decrease in the levels of TC, TG, LDL-C, VLDL-C particularly treatment with CESC at the dose of 200 mg/kg b.w resulted in significant decrease in levels of TC (67.60%), TG (47.89%), LDL-C (85.80%) and VLDL-C (47.89%) whereas HDL-C levels are significant to standard. In cholesterol induced hyperlipidemic model, the groups treated with the extracts of S. cerasoideum and pitavastatin demonstrated a significant decrease with the CESC and MESC at low doses in the serum levels TC (68.68%), TG (60.22%), LDL-C (85.44%), VLDL-C (70.71%) besides an increase in serum HDL-C (62.26%) levels when compared to cholesterol-induced hyperlipidemic control group. The treated groups of S. cerasoideum caused a significant decrease in the levels of SOD, CAT and GSH activities of MESC at the doses of 400 mg/kg/day and 10 mg/kg/day compared to the cholesterol-induced hyperlipidemic control group. It was observed from the histopathological findings that the rats fed with S. cerasoideum extracts showed a decrease in moderate microvesicular changes caused by cholesterol feedings. Results suggest that the methanolic followed by chloroform extracts of S. cerasoideum containing polyphenols and flavanols possess significant antioxidant and antihyperlipidemic activities.
Authors and Affiliations
S. Sadik et al.
Keywords
Related Articles
- EP ID EP581516
- DOI 10.13040/IJPSR.0975-8232.10(6).3062-72
- Views 83
- Downloads 0
FLAVONOIDS IMPACT ON PREVENTION AND TREATMENT OF OBESITY AND RELATED METABOLIC RISK FACTORS
Metabolic syndrome, the most prevailing health concern worldwide, and their incidences are increasing at a very high rate, resulting in enormous social costs. Obesity is a measure risk factor for non-communicable disease...
FORMULATION AND EVALUATION OF pH TRIGGERED IN-SITU OCULAR GEL OF OFLOXACIN
Rapid precorneal elimination of the drug in conventional ophthalmic solution leads to poor bioavailability and less therapeutic response, which can be overcome by the use of in-situ gel forming system that is instilled i...
COMPARATIVE DISSOLUTION BEHAVIOUR OF TEN MARKETED CHLORAMPHENICOL CAPSULES IN INDONESIA
Background: Chloramphenicol capsules are found in several brands with different prices in the market. This study aimed to obtain in-vitro biopharmaceutics quality data from the generic and branded name products. Methods:...
Evaluation of Antidiabetic Activity of Triumfetta Pilosa Roth in Streptozotocin-Induced Diabetic Rats
The present study aims to evaluate medicinal use of Triumfetta pilosa for the treatment of diabetes. Antidiabetic activity of ethanolic extract of Triumfetta Pilosa Roth was evaluated for in-vivo hypoglycemic activity u...
EFFECT OF EDAPHIC FACTORS ON MAJOR SECONDARY METABOLITES OF TINOSPORA CORDIFOLIA AND NEEM GUDUCHI WITH RESPECT TO THEIR IMMUNOMODULATORY EFFECT
Tinospora cordifolia is a requisite medicinal plant, has been used for the treatment of various diseases and has been recommended for improving the immune system mentioned in Ayurveda and other systems of medicine as a m...