IN-VIVO ANTIOXIDANT EFFECT OF ABROMA AUGUSTA IN DIABETES INDUCED OXIDATIVE STRESS
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 7
Abstract
The present study was aimed to investigate the In-vivo antioxidant activity of roots of Abroma augusta in streptozotocin-nicotinamide induced Type-II diabetes. The extraction (Hot continuous extraction process) was carried out with solvents of different polarity. Commercially available Vit-E (100 mg/kg b.w.) was used as a standard drug. In-vivo antioxidant activity of plant extracts (250 mg/kg b.w.) was assessed by measuring SOD, CAT and LPO in the blood of Type-II diabetic animals. The results of the study revealed the significant effect on SOD, CAT and LPO level in animals treated with petroleum ether extract (p<0.0001) followed by aqueous extract (p<0.001) of A. augusta significantly as compared to diabetic control. The results of the study suggested the antioxidant activity of plant extract which prevents from oxidative stress and provide protection to vital tissues like liver, kidney, heart etc.
Authors and Affiliations
Rekha Bisht
Keywords
Related Articles
- EP ID EP302206
- DOI -
- Views 61
- Downloads 0
IN-VITRO RELEASE STUDY AND ANTIMICROBIAL PROPERTY EVALUATION OF OFLOXACIN LOADED POLY (2-HYDROXYETHYL METHACRYLATE) / POLY (CAPROLACTONE) / POLY (ETHYLENE GLYCOL) HYDROGEL SYSTEM FOR BURN WOUND MANAGEMENT
Monomer 2-hydroxy ethyl methacrylate containing small amounts of poly(caprolactone) and poly(ethylene glycol) incorporated with an antibiotic ofloxacin was polymerized by photopolymerization technique using 2,4,6 trimeth...
Drug utilization evaluation of antibiotics in district hospital Rudraprayag
Drug utilization is very important for antibiotics as they are widely used in hospitals and their in appropriate use may lead to resistance. To check this irrational use of antibiotics and promote rational use the presen...
FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF ROSUVASTATIN: RESEARCH ARTICLE
The objective of the present study was to formulate and evaluate fast dissolving tablets of Rosuvastatin (BCS Class II drug) to enhance solubility, improve bioavailability and patient compliance especially for the paedia...
DESIGN AND EVALUATION OF PRONIOSOMES AS DRUG CARRIER FOR OCULAR DELIVERY OF LEVOFLOXACIN
na
Formulation and evaluation of chitosan containing mucoadhesive buccal patches of metoprolol succinate
Mucoadhesive buccal patches containing metoprolol succinate were prepared using the solvent casting method. Chitosan was used as bioadhesive polymer and different ratios of chitosan to PVP K-30 were used. The patches wer...