IN-VIVO ANTIOXIDANT EFFECT OF ABROMA AUGUSTA IN DIABETES INDUCED OXIDATIVE STRESS
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 7
Abstract
The present study was aimed to investigate the In-vivo antioxidant activity of roots of Abroma augusta in streptozotocin-nicotinamide induced Type-II diabetes. The extraction (Hot continuous extraction process) was carried out with solvents of different polarity. Commercially available Vit-E (100 mg/kg b.w.) was used as a standard drug. In-vivo antioxidant activity of plant extracts (250 mg/kg b.w.) was assessed by measuring SOD, CAT and LPO in the blood of Type-II diabetic animals. The results of the study revealed the significant effect on SOD, CAT and LPO level in animals treated with petroleum ether extract (p<0.0001) followed by aqueous extract (p<0.001) of A. augusta significantly as compared to diabetic control. The results of the study suggested the antioxidant activity of plant extract which prevents from oxidative stress and provide protection to vital tissues like liver, kidney, heart etc.
Authors and Affiliations
Rekha Bisht
Assessment of Fatty Acid, Proximate and Quantitative Phytochemical Compositions of Matured Stem of Costus afer (Bush Cane).
This study estimated the fatty acid, proximate and quantitative phytochemical compositions of Costus afer matured stem collected from Choba campus of University of Port Harcourt, in Choba community, Rivers State. This wa...
MANGIFERIN PROTECTS RENAL IMPAIRMENT AGAINST BENZO(A)PYRENE INDUCED TOXICITY BY REGULATING MITOCHONDRIAL AND DNA INTEGRITY
Contaminated food and water ingestion and inhalation of polycyclic aromatic hydrocarbon are the main sources of human exposure to benzo(a)pyrene leading to cause renal injury and provoking a nephropathic response. Mangif...
SUPERCRITICAL FLUID TECHNOLOGY: AN INNOVATIVE APPROACH USED TO ENHANCE SOLUBILITY OF WATER INSOLUBLE DRUGS
Certain techniques are used for the preparation of solid dispersions and used to enhance the solubility of water insoluble drugs. One of its techniques is supercritical fluid technology that is used for the preparation o...
ADVERSE DRUG REACTIONS: A COMPREHENSIVE REVIEW
Adverse drug reactions are the undesirable unintended response of the drug which occurs at the doses normally used for the diagnosis, prophylaxis and treatment of the patient. ADR is the harmful effect other than desirab...
Assessment and Comparison of Antimicrobials Prescription in Indoor Patients of Departments of General Medicine and Pediatric Medicine in a Tertiary Care Hospital in Eastern India
Objective: Antimicrobials are among the most commonly prescribed drugs. Irrational prescribing leads to antimicrobial resistance and treatment failure. The purpose of drug use evaluation is to ensure that drugs are used...