In-vivo biological effect of Carica papaya leaf extracts on P-407 induced hyperlipidemic Albino Wistar rats
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 8
Abstract
To determine the biological effect of Carica papaya leaves extracts Poloxamer induced hyperlipidemia. Thirty-five healthy albino rats of the same sexes weighing 150-200g were divided into seven; group given feed and water only, group induced by an intra-peritoneal injection of P-407, groups induced and treated with methanol, ethanol, ethyl acetate, n-butanol and n-hexane leaves extracts. In all the groups, P-407 and the extracts were administered at a dose of 1000mg/kg and 30mg/kg body weight respectively. At the end of the 14 day, the animals were sacrificed and blood sample were collected for determination of serum levels of: Total cholesterol (TC), Triacylglycerides (TG), Low-density lipoprotein (LDL) and High-density lipoprotein (HDL). The studies showed that animals in induced treated groups significantly (P<0.05) lower serum levels of TC, TG, LDL and significantly (P<0.05) increased HDL when compared to the P-407 induced hyperlipidemia control. The studies show the phytotherapeutic effect of Carica papaya leaves extracts (methanol, ethanol, ethyl acetate, n-butanol and n-hexane) in P-407 induced hyperlipidemia.
Authors and Affiliations
Sheneni, Victor Duniya
Keywords
Related Articles
- EP ID EP519672
- DOI -
- Views 72
- Downloads 0
Torsion of Ovarian Dermoid Cyst with MRKH Syndrome - A Rare Presentation
The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is characterized by congenital aplasia of the uterus and the upper part (2/3) of the vagina in women showing normal development of secondary sexual characteristics and a...
A Rare Collision Tumor of Ovary
Collision tumors represent a coexistence of two adjacent tumors but histologically distinct tumors without admixture in the same tissue or organ. Collision tumors in ovary are a rare entity and combination of mucinous cy...
Characterization and Clinical Significance of Coagulase –Negative Staphylococci
Background: Coagulase-negative staphylococci are normal commensal of human skin. They are considered as non-pathogenic and rarely reported as to cause severe infections. But their important role as pathogen and the incre...
A Study of Benign and Malignant Lesions of Prostate in a Tertiary Care Hospital
Background: Prostatic disease is responsible for significant morbidity and mortality in men throughout the world. The current study is undertaken to assess the spectrum of tumors affecting the prostate and the utility of...
A Case Report on Acquired Pure Red Cell Aplasia in a Patient of Rheumatoid Arthritis
Pure red cell aplasia (PRCA) is a clinical syndrome defined by the absence of mature erythroid precursors in another wise normocellular bone marrow. PRCA is considered to be an extra articular manifestation of rheumatoid...