In vivo effect of antituberculous drugs on methimazole induced hepatotoxicity in BALB/c mice
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2017, Vol 3, Issue 1
Abstract
Abstract: The effect of isoniazid and rifampicin on metabolism dependent hepatotoxicity of methimazole (MMI) was studied in BALB/c mice. Hepatic damage was induced by single intraperitoneal dose of MMI (1000mg/kg). Pretreatment with isoniazid and rifampicin was carried out in separate groups for ten days and six days respectively prior to administration of methimazole. The extent of liver injury was determined by measuring alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) along with histopathological analysis of liver samples. The elevation of liver enzyme levels caused by MMI was augmented by rifampicin however; isoniazid exhibited a protective role by preventing MMI induced escalation in serum ALT, AST and ALP. The biochemical findings were also reflected in histological examination. These findings suggest that activity of microsomal enzymes can influence the hepatotoxic potential of MMI. Keywords: Methimazole, isoniazid, rifampicin, hepatotoxicity
Authors and Affiliations
Zunera Hakim, Akbar Waheed, Bareera Hakim, Najamul Hasan
Keywords
Related Articles
- EP ID EP389240
- DOI -
- Views 121
- Downloads 0
Therapeutic Potential of Herbal Ethosome in Applied Nanotechnology
Abstract:Phytomedicines are becoming more popular in the world for their ability to cure diseases with less toxicity and better therapeutic efficacy. Herbal medicines may also have disadvantages of poor bioavailability,...
Haemovigilance Study in a Tertiary Care Hospital in Western Odisha
Blood transfusion is a routine, life-saving medical intervention which is generally regarded as safe when done appropriately, but it is not absolutely free from adverse reaction. The aim of the study was to analyze the A...
Molecular Biology of Breast Cancer in the Niger Delta Region of Nigeria: A Pilot Study
Abstract: Breast cancer is the commonest cause of cancer related death among women globally. The incidence is lowest but increasing in Africa and accompanied by increased mortality. Different expression patterns of oestr...
Bioactive molecules present in Plants play a potential role in the Treatment of Spasticity in Multiple Sclerosis: a new perspective in Future
Abstract: Multiple sclerosis (MS) is a chronic disabling disease of the CNS that affects people during early adulthood. Despite several US FDA-approved medications, the treatment options in MS are limited. Many people wi...
Evaluation of Chronic Haematological and Neurological Effects of Organophosphates Pesticides Exposure in Children of Rural Population
Abstract:This is an award-winning study of its kind first time conducted in the rural areas of Indore Madhya Pradesh with the aim of evaluating the subclinical morbidity and mortality pattern of the chronic hematological...