IN VIVO EVALUATION OF IMMUNOMODULATORY POTENTIAL OF FERULIC ACID
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2016, Vol 7, Issue 3
Abstract
Immunology is a branch of biomedical science that involves all aspects of the immune system that recognize pathogens and initiate defense response that involve induction, expression, amplification or inhibition of phase of the immune response. Plant based medicines have potential immunomodulatory activity that can justify their use in past. Ferulic acid (FA) is a polyphenol abundant in several plants, possesses activity, such as antioxidant, antimicrobial, anti-inflammatory, anti-thrombosis, anti-cancer and also used in age-related diseases such as neurodegenerative disorders, cardiovascular diseases and diabetes. The study was proposed to determine immunomodulatory effects of FA. Assessment of immunomodulatory activity of FA was done by carbon clearance test, delayed type hypersensitivity (DTH) reaction, neutrophils adhesion test, effect on serum immunoglobulins and cyclophosphamide induced neutropenia. FA at doses 200 mg/kg produced significant increase in phagocytic index (P<0.01) which indicated stimulation of reticuloendothelial system, neutrophil count (P<0.05) in nylon fibers which causes the stimulation of neutrophils towards the site of inflammation, the serum immunoglobulin levels (P<0.05) shows direct measure of T and B cell activity, TLC count (P<0.05) and prevent neutropenia through activation of macrophages and increase in DTH response (P<0.05) which indicate stimulatory effect on lymphocyte. On the basis of present investigation, it can be concluded that FA has potential to stimulate overall immune system in the experimental animals.
Authors and Affiliations
Mandeep Singh , Bhrigu Das, Rahul Trivedi
Keywords
Related Articles
- EP ID EP90670
- DOI 10.7897/2230-8407.07321
- Views 109
- Downloads 0
DIURETIC ACTIVITY OF BUTEA MONOSPERMA FLOWERS EXTRACT
Kidney, as excretory organ of our body serves important function of excretion of waste products, regulation of fluid volume and electrolyte content etc. Damage to kidney can lead to severe life threatening complications....
IN SILICO DOCKING ANALYSIS OF THE COMPOUNDS OF ORTHOSIPHON STAMINEUS FOR THE ANTICANCER ACTIVITY
The aim of the present study is to investigate the inhibitory activity of the compounds of Orthosiphon stamineus on cancer by molecular docking studies and to analyse the ADME/T properties of the compounds. Compound 1- N...
SIMULTANEOUS ESTIMATION AND VALIDATION OF PARACETAMOL, CHLORPHENIRAMINE MALEATE, PHENYLEPHRINE HYDROCHLORIDE, CAFFEINE AND ITS STRESS DEGRADATION STUDIES USING UV VISIBLE SPECTROSCOPY
A simple, precise, accurate and economic simultaneous UV spectrophotometric method has been developed for the estimation of Paracetamol, Chlorpheniramine Maleate, Phenylephrine Hydrochloride and Caffeine in tablet formul...
PHARMACEUTICAL AND ANALYTICAL STUDY OF RASASINDURA CHANDRODAYA RASA
Rasashatra is a science of minerals and its main aim to gain Drama, Artha, Kam, Moksha. In Rasashatra there are many methods to control or convert the mercury in the form which is beneficial to our body for curing the di...
BERBERIS ASIATICA FUTURE BASED EXCELLENT FRUIT IN NUTRITIONAL PROFILE, ANTIMICROBIAL AND ANTIOXIDANT INGREDIENTS
The aim of the present study was to calculate in vitro antimicrobial activity of Berberis asiatica fruit extracts against 13 Gram-positive and Gram-negative bacteria and fungus strains. The ethanolic fruit extracts of Be...