In vivo hypoglycemic investigation, antihyperglycemic and antihyperlipidemic potentials of Pereskia bleo Kunth. in normal and streptozotocin-induced diabetic rats
Journal Title: Asian Pacific Journal of Tropical Biomedicine - Year 2019, Vol 9, Issue 2
Abstract
Objective: To elucidate the in vivo hypoglycemic capability, antihyperglycemic and antihyperlipidemic activities of Pereskia bleo (Kunth) leaves extracts and bioactive fraction. Methods: The various solvent extracts of Pereskia bleo were investigated for the hypoglycemic and antihyperglycemic activities using a relevant in vivo normal rat model and streptozotocin-induced diabetic rat model with glibenclamide and metformin utilized as positive controls. The effects of the most potent extract and its bioactive fraction on the insulin level, lipid profile and body weight of the diabetic rats were also analyzed. Results: All the extracts showed no hypoglycemic effect while petroleum ether, chloroform and aqueous extracts demonstrated significant (P<0.05) reduction in blood sugar level in the intraperitoneal glucose tolerance test. Aqueous extract and aqueous fraction significantly (P<0.05) reduced the blood glucose level in streptozotocin-induced diabetic rats as early as day 6 compared to the diabetic control as well as significantly restored the serum insulin of diabetic rats. Moreover, the aqueous extract and aqueous fraction disclosed a significant (P<0.05) reduction in total cholesterol, triglycerides, and low-density lipoprotein levels. An elevation in high-density lipoprotein as well as improved body weight loss of the diabetic rats were also observed. Conclusions: In summary, Pereskia bleo appears effective in the management of diabetes and correlated impairments arising from high blood sugar level. Further studies will possibly bring about the discovery of effective and secure plant derived antidiabetic drugs.
Authors and Affiliations
Anis Najwa Abdul Rani, Roziahanim Mahmud, Norliyana Amran, Mohd Zaini A smawi, Nornisah Mohamed, Shanmugapriya Perumal
Keywords
Related Articles
- EP ID EP447965
- DOI 10.4103/2221-1691.250858
- Views 21
- Downloads 0
Toxicological evaluation and protective effect of ethanolic leaf extract of Launaea taraxacifolia on gentamicin induced rat kidney injury
Objective: To evaluate the toxic potential of Launaea taraxacifolia leaf extract (LTE) in rats within 14 d of oral administration and also assess the potential of LTE in protecting against kidney injury induced by gentam...
Immunomodulatory activity of butanol fraction of Gentiana olivieri Griseb. on Balb/C mice
Objective To explore the immunomodulatory properties of 80% ethanol extract and butanol fraction of Gentiana olivieri (G. olivieri) Griseb on Balb/C mice. Methods The study was performed with basic models of immunomod...
A comprehensive review on phytopharmacological investigations of Acacia auriculiformis A.Cunn. ex Benth
Acacia auriculiformis A.Cunn. ex Benth. is a perennial shrub having a wide range of medicinal potentials and is widely distributed throughout the world. It is being used traditionally to overcome various medical complica...
Fate of polyphenols in pili (Canarium ovatum Engl.) pomace after in vitro simulated digestion
Objective: To evaluate the stability and bioavailability of polyphenols in pili (Canarium ovatum Engl.) pomace during simulated in vitro digestion. Methods: Freeze-dried pili pomace was subjected to in vitro digestion si...
Phytochemical analysis and anti-oxidant activities of Albuca bracteata Jacq. and Albuca setosa Jacq bulb extracts used for the management of diabetes in the Eastern Cape, South Africa
Objective: The bulb of Albuca bracteata Jacq., and Albuca setosa commonly used in Eastern Cape Province of South Africa for the treatment of several types of disease conditions including diabetes, was investigated for th...