In-Vivo studies of anti-parkinson activity of Ropinirole Hydrochloride loaded in microsphere for brain targeting by intranasal delivery
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2017, Vol 6, Issue 2
Abstract
Objective In the present study, we evaluated anti-Parkinson’s activity of Ropinirole hydrochloride loaded in microsphere by intranasal delivery for brain targeting. Material & Method All animal experiments were approved and performed in Malla Reddy College of Pharmacy accordance with the guidelines of Institutional Animal Ethics Committee (CPCSEA Registration No: 1217/PO/RE/S/2008). Result For In-Vivo evaluation of nasal microspheres of Ropinirole Hydrochloride, rabbit was chosen as a model for study because the blood volume of the rabbit is sufficiently large (approximately 300 ml) to permit frequent blood sampling and allow a full characterization of the absorption and determination of the pharmacokinetic profile of the drug. The Cmax after oral dosing was found to be 107.833±1.567 ng/ml and the corresponding Tmax was at 1.86±0.066 hrs. Conclusion From all the parameters studied, it can be concluded that combination of Carbopol 974P and guar gum is better mucoadhesive polymer for the formulation of mucoadhesive microspheres of Ropinirole Hydrochloride for intranasal administration. Thus, the formulated microspheres seem to be a potential candidate as intranasal controlled drug delivery system for treatment of Parkinson’s disease.
Authors and Affiliations
Shubhrajit Mantry
Keywords
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