INACTIVATION OF USP (RV2623) PROTEIN OF MYCOBACTERIUM TUBERCULOSIS H37RV USING STRUCTURE –BASED DRUG DESIGN APPROACH
Journal Title: World Journal of Pharmaceutical Research - Year 2019, Vol 8, Issue 6
Abstract
Tuberculosis is a serious threat worldwide. Mycobacterium tuberculosis, the causative agent is very successful intracellular pathogen due to having various facilities for survival. Dormancy/latency is one of these abilities as it constrains the eradication of the disease. The case facilitated by universal stress proteins (USPs) which are induced upon exposure to stresses. This study aimed to look for inhibitors for the most important USP protein RV2623, using computational structure-based drug design approach. Four inhibitors were obtained directly or after modifications, those were docked strongly with chain F and chain H of the protein (pdb ID 3cis).
Authors and Affiliations
Dr. Zahra M. Al-Khafaji
Keywords
Related Articles
- EP ID EP672537
- DOI -
- Views 132
- Downloads 0
A REVIEW ON “PHARMACOGNOSTIC, PHYTOCHEMICAL STUDY OF AZADIRACHTA INDICA” BARK EXTRACTS
Azadiracta indica A. Juss (Meliaceae) commonly known as Neem, is found throughout India and is known to have many wonderous properties from ancient times. These A. indica shows different medicinal properties like antiulc...
QUERCUS INFECTORIA (MAZU): A REVIEW
Quercus infectoria Olivier (Fagaceae) is a small tree found in Greece, Asia minor and Iran. The galls arise on young branches of this tree as a result of attack by an insect, gall wasp. In Unani system of medicine, galls...
VOLTAMMETRIC DETERMINATION OF SULFAMETHOXAZOLE BY NICKEL HEXACYANOFERRATE FILM-CHEMICALLY MODIFIED ELECTRODE
Both human and veterinary medicine have relied on the antibiotic sulfamethoxazole to treat infections. However, high consumption of this compound culminates in environmental and public health problems. In this context, h...
ETIOPATHOGENESIS & SHATKRIYAKALA OF MUTRAGHATA (RETENTION OF URINE): A REVIEW STUDY
Now a days, it is seems that several patients are suffering from different types of disorders of Mutravaha Srotas. So, each physician should know the details like nidana (etiological factor), samprapti (pathogenesis), la...
ISOLATION AND IDENTIFICATION OF ESCHERICHIA COLI O157:H7, O26:H8 AND O111:H8 USING CULTURE AND SEROLOGICAL TECHNIQUE IN KHARTOUM STATE SUDAN – 2019
Most E.coli are considered as commensal of the human and animals intestine and are harmless. Some serotypes are pathogenic. One of the most important pathogenic serotype is E. coli O157:H7 which cause Enterohaemorrhagic...