Inadvertent doping with the use of herbal preparations: is it a reality?
Journal Title: International Journal of Pharmaceutical Chemistry and Analysis - Year 2017, Vol 4, Issue 1
Abstract
The use of performance enhancing drugs in sports is prohibited by World Anti-doping Agency (WADA).(1) Herbal preparations are usually considered safe due to least side effects but may contain substances which are prohibited in sports. Athletes often take these preparations for therapeutic purpose without considering the risks of an inadvertent doping. A study on the screening of various labelled and unlabelled Indian Ayurvedic herbal preparations to identify the substance of abuse was conducted. A total of hundred and two labelled and sixteen unlabelled herbal Ayurvedic preparations used for different therapeutic indications were tested for screening of approximately one twenty drugs prohibited by WADA. Out of hundred and two labelled herbal preparations, sixteen showed presence of Strychnine. However, out of these sixteen herbal preparations, only four preparations declared presence of strychnine on the label. Strychnine is a stimulant which is prohibited by WADA during in competition testing. Out of sixteen unlabelled preparations, two showed presence of Nicotine. The study shows that the labelled/unlabelled herbal preparations may contain undeclared substances prohibited by WADA. The excretion study showed levels of strychnine above WADA Minimum Required Performance Levels (MRPL) thereby leading to positive dope test.
Authors and Affiliations
Mahua Chakraborty, Sachin Dubey, Alka Beotra, Sarika . , Jaspal S. Sandhu
Animal models of chronic kidney disease: Screening tool to investigate nephroprotective effects of natural products
Animals are used as experimental models to reproduce human diseases To date various animal models have been successfully developed by numerous methods to simulate human diseases including chronic kidney disease CKD Such...
Brief update on management of hypertension in diabetic patients
Nowadays there is increased prevalence of co-morbidity of hypertension and diabetes. Hypertension has become such a bigger health problem as it does not show any manifestation of it until it gets seriously complicated. H...
Preparation of BSA-EA-MWCNTs submicron hybrid composite
Bovine serum albumin-egg albumin-multiwalled carbon nanotubes (BSA-EA-MWCNTs) submicron hybrid compositewas prepared by using suitable organic solvent and emulsifier as surface modifier. The prepared submicron hybrid com...
Simultaneous quantitative estimation of Telmisartan and Hydrochlorothiazide in bulk and marketed tablet formulation by HPTLC-a Stability indicating method
A stability indicating HPTLC method is proposed for the simultaneous estimation of telmisartan and hydrochlorothiazide in bulk and tablet formulation. Well resolved chromatogram was obtained on TLC plates coated with sil...
A mini review on thiadiazole compounds and their pharmacological interest
Various 134thiazole derivatives have been reported to exhibit various biological activities The 134thiadiazole derivatives found to have diverse pharmacological activities such as insecticidal herbicidal antiviral antitu...