Incidence and antibiotic sensitivity pattern of New Delhi metallo - β - latamase - 1 (NDM-1) producers among carbapenem resistant enterobacteriaceae in a tertiary care teaching hospital, Bareilly: A cross sectional study
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2018, Vol 5, Issue 1
Abstract
Objectives Antibiotic resistance in microorganisms has become a critical health issue these days and has evolved to become a worldwide health threat Carbapenemresistant Enterbactriaceae CRE is one example which really is a nightmare bacteria resistant to most and in some cases all antibiotics The commonest cause is ellaboration of various types of carbapenemases amongst which the recent detection of New Delhi metallo betalactamase1 NDM1 a superbug further compounded the problem So the present study was undertaken to study the pattern of carbapenem resistance and role of carbapenamase blaNDM1 gene towards itMaterials and Methods The study was a cross sectional study conducted in the department of Pharmacology in collaboration with Microbiology and Biochemistry SRMS IMS Bareilly All clinical isolates their sensitivity pattern and MBL detection of carbapenem resistant ESBLS were obtained from Microbiology records blaNDM1 gene was detected by PCRResults A total of 312 ESBL producers were isolated Out of which 42 were found to be carbapenem resistant Amongst these 1905 8 were found to be MBL positive and 5 625 MBL positive isolates were NDM positive ESBL producers were sensitive to very few antibiotics and NDM producers were sensitive only to polypeptide antibioticsConclusion ESBL is a great problem for gram negative organisms and now the frequency of carbapenem resistance is high which has limited antibiotics available for the treatment Furthermore carbapenemase blaNDM1 gene has also shown a substantial role This high incidence of antibacterial resistance demands development of newer antibioticsKeywordsnbspCarbapenem resistance ESBL blaNDM1 MBL
Authors and Affiliations
Anju Saxena, Sujata Singh, Rahul Kumar Goyal, Jaspreet Kaur, Sumit Saxena
Keywords
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- EP ID EP478531
- DOI 10.18231/2393-9087.2018.0004
- Views 68
- Downloads 0
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