Incidence and Clinical Profile of Triple Negative Breast Cancer (TNBC)
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 1
Abstract
Objective: To study the incidence and clinical profile of triple negative breast cancer (TNBC) patients.MethodsPatients with histopathological evidence of breast cancer were evaluated for ER, PR HER-2 neu by immunohistochemistry. Their incidence and clinical profile were studied and result were analyzed statistically. Results: 196 out of 600 (32.67%) patients had TNBC. Patients with TNBC had younger age at presentation (51.48% were <50 years age) when compared to non-TNBC group (37.56% younger than 50). Patients with TNBC had significantly large tumor size (>5 Cm 24.85% vs 15.73%, p=0.012), higher node positivity (74.56% vs 64.86%, p=0.032), high recurrence whether distant or local (27.22% vs 16%, p=0.03), higher histopathological grade (55.90% vs 41.14%, p=0.05) when compared for non-TNBC group. 3 year DFS (Disease Free Survival) was significant lower in TNBC group (74.24% vs 85.66%, p<0.05). 5 year DFS rate was less in TNBC group, but not statistically significant. Conclusions:TNBC was found more commonly in younger patients with large tumor size, high node positivity, more recurrence and less survival, suggesting an aggressive behavior when compared to non-TNBC group.
Authors and Affiliations
Deepak Kumar rathi, Sarita Chaudhary, Mukta Sukhadia, Minaxi Sharma, Siddharth Verma
Keywords
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