INCIDENCE AND RISK FACTORS FOCUSING ON RADIOLOGY: REACTIONS AFTER EXPOSURE TO NON-IONIC CONTRAST MEDIA
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 10
Abstract
Computed tomography (CT) imaging has rapidly become a commonplace diagnostic tool due to its utility in a wide range of diseases. To prospectively evaluate the incidence of reactions after exposure to Non-Ionic Contrast media (NICM), and to identify potential risk factors, with a focus on fasting duration for solid food and fluids, separately. Methods: From July to October 2017, 229 patients (117 men, 112 women; median age, 53.2 years; range, 04-90 years) undergoing ICM-enhanced CT were included in this study. Reactions after exposure to ICM exposure were assessed on a 3-point scale (mild, moderate, severe). Patients’ characteristics and the fasting duration were evaluated to identify risk factors using logistic regression analysis. Results: Of the 229 patients, 8 experienced hypersensibility reaction, no patients experienced vomiting. Multi-variate regression analysis revealed that a history of drug hypersensitivity (3.49%) was independent risk factors for nausea. Of the patients who presented hypersensitivity reactions, 12.5% were diabetic, 12.5% had asthma, 50% had systemic arterial hypertension, 50% had dyslipidemia, 0% had renal disease, 25% had no associated alterations (asthma, hypertension, diabetes, dyslipidemia, renal diseases. Conclusions: The adverse reactions to ICM agents were consisting in predictors analyzers like an allergic history to contrast agents, diabetic, asthma, systemic arterial hypertension, dyslipidemia, renal disease and urticaria, history of the previous allergy to drugs other than contrast agents. ICM Hypersensitive reactions occurred in 1.31% of patients. Our results showed that clinical decision based on patient clinical records resulted in a decrease of several immediate reactions incidence.
Authors and Affiliations
Wanessa Silva Garcia Medina
Keywords
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