Incidence and Severity of Oral Mucositis in Patients of Head and Neck Cancers Receiving Definitive Radiotherapy with or without Chemotherapy: A Hospital Based Study
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 2
Abstract
Background: Head and neck cancers are among the ten most frequent cancers in the world and constitute 5% of all cancers worldwide. In developing countries like ours, cancer of the head and neck is among one of the commonest cancers. They account for one fourth of male and one-tenth of female cancers in India. Radiotherapy, with or without chemotherapy, is the mainstay of the treatment and oral mucositis is one of the major complaint and side-effect of the treatment in head and neck cancer patients. Material and Method: The present study comprised of total of 150 head & neck cancer patients receiving treatment at MD Oswal Cancer Hospital were enrolled in this study. Any Head and Neck Squamous cell carcinoma (AJCC Stage I-IV, M0 vide appendix no. I) patient receiving Radiation dose more than or equal to 56 gray, weekly concomitant chemoradiation in the form of Cis-platinum, Gemcitabine or Paclitaxel alternating with Gemcitabine were enrolled in this study. Results: Oral mucositis incidence was noted in 100% of the patients with chemo-radiation & was irrespective of chemotherapy used. The frequency of severe oral mucositis was 50% in radiotherapy alone group while 54.03% in chemoradiation group. Incidence of mucositis grade IV was more with cis-platinum being used as radio-sensitizer (62.9%) and was seen least in the gemcitabine arm (41.4%). Mean treatment time in all patients was almost same and around 59 days and it was not affected by the chemotherapy used. Conclusion: Severe oral mucositis (grade III and IV) was observed more in smokers, alcoholics, diabetics, opium addicts and patients having bad ODH. Mucositis resolves within 4-5 weeks period after the completion of treatment.
Authors and Affiliations
Pardeep Garg, Parveen Kaur, Rajesh Vashistha, Rupinder Singh, Ishu Sharma
Keywords
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- EP ID EP544135
- DOI 10.21276/ijmrp.2017.3.2.043
- Views 40
- Downloads 0
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