Incidence of Early Onset Septicemia, Isolation and Resistant Patterns of Causative Organisms: A Study in a Tertiary Care Hospital A.P.
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 2
Abstract
Septicemia is a major problem in neonateswith multiresistant organisms. Aim: This study is aimed to know the prevalence and resistant patterns of the isolated organisms. Materials & Methods: A total of 426 neonates(< 1week of age) suspected septicemia admitted in NICU enrolled over a period of 6 months.1-2 ml of blood collected in aseptic conditions inoculated immediately into 5 ml of brain heart infusion broth with 0.025% Sodium polyanethol sulfonate as anticoagulant. The broths were subcultured after overnight incubation on chocolate agar, MacConkey agar and 5%sheep blood agar. organisms isolated kept for biochemical tests for confirmation then checked for Antibiotic sensitivity by Kirby-Bauer disk diffusion method. Results: Out of 426 cases studied, growth of bacteria was obtained in 44.1% of blood samples. Most frequent organism was Klebsiella spp(25.5%). followed by E. coli(22.3%) Enterobacter spp (18.6%), CONS (14.8%), S. aureus (11.7%).There is significant association with maternal & fetal risk factor like preterm labour and LBW. The antimicrobial susceptibility testing revealed that resistance to penicillin was frequent. Resistance to amikacin was not common for GPC. None of the gram positive isolates were resistant to the glycopeptides - vancomycin and teicoplanin. Most of the gram negative isolates of Enterobacteriaceae family were resistant to ampicillin and amoxicillin. Resistance to amikacin was less frequent than resistance to gentamicin. Enterobacteriawere less frequently resistant to ciprofloxacin. Conclusion: Our study highlights the need of empirical therapy in neonates with risk factors and importance of knowledge about the causative agents and their sensitivity patterns to reduce the mortality rate of neonates
Authors and Affiliations
Muni Lakshmi Ponugoti
Keywords
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