INCIDENCE OF NUMERICAL CHROMOSOMAL ANOMALIES IN PATIENTS OF ACUTE MYELOID LEUKEMIA
Journal Title: JOURNAL OF ANATOMICAL SCIENCES - Year 2017, Vol 25, Issue 1
Abstract
Introduction: Acute myeloid leukemia (AML) is a tumor of hematopoietic progenitors caused by acquired oncogenic mutations that impede differentiation, leading to the accumulation of immature myeloid blasts in the marrow. The single most important prognostic factor in AML is cytogenetics, which determine the prognosis and probability of relapse after treatment. Hence the cytogenetic analysis of AML patients plays a great role in prognosis and treatment. Material and methods: Karyogram of diagnosed patients of AML was prepared from bone marrow and peripheral blood. This study was conducted in the Cytogenetic Laboratory of the Department of Anatomy, King George’s Medical University UP, Lucknow. Patients were screened in the Department of Pediatrics Medicine and samples were collected from the Pathology Department. Observations and Results: We observed the frequency of chromosomal aberrations in different age groups and sex. Out of 22 successful cases 12 cases (54.54%) exhibited abnormal karyogram and 10 cases (45.45%) showed normal karyogram. Numerical chromosomal abnormality was observed in 31.81% cases. Most common abnormality observed was trisomy 21 (13.63%) followed by trisomy 8 (9.09%) and trisomy 11 associated with trisomy 21 (4.54%). Conclusion: Trisomy 21 was found to be most prevalent in UP region as compared to trisomy 8 and trisomy 11 associated with trisomy 21. Trisomy 21 has intermediate risk for developing AML, trisomy 8 is likely to be a disease modulating secondary event and trisomy 11 has poor prognostic value in AML patients. Hence the cytogenetic analysis of AML patients plays a great role in prognosis and treatment.
Authors and Affiliations
Rakesh Verma
Keywords
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