Incidence of sub clinical thyroid dysfunction among asymptomatic adult population
Journal Title: International Archives of Integrated Medicine - Year 2017, Vol 4, Issue 11
Abstract
Background: Patients with subclinical thyroid dysfunction are universally encountered in routine clinical practice. Advanced diagnostic techniques have created new categories of thyroid disorders such as subclinical hypo-and-hyperthyroidism. The management of subclinical thyroid dysfunction is controversial. Patients with subclinical thyroid dysfunction may have vague, nonspecific symptoms that do not aid the clinical apperception. This study aimed to screen the normal adult population for the incidence of subclinical thyroid dysfunction and discuss the optimal management strategy. Materials and methods: Four hundred subjects with no clinical evidence of thyroid dysfunction were included in the present study. Elaborate history in the form of a symptom questionnaire was obtained and clinical examination was performed. Laboratory analysis of thyroid function was done by electro-chemiluminescence immunoassay (ECLIA). Patients with normal free thyroxine (FT4) and tri-iodothyronine levels (T3) were further classified into subclinical hypo/hyperthyroid based on the serum thyroid-stimulating hormone (TSH) levels. The incidence of subclinical thyroid disorder in the sample population was detected and optimal management strategies were followed as per the European thyroid association (ETA) guidelines. Results: The normal TSH value by ECLIA was 0.27 - 4.2μIU/ml. Seventeen (4.25%) out of four hundred subjects included in the present study were found to have subclinical thyroid dysfunction. The Ratio of subclinical hypothyroid cases to subclinical hyperthyroid cases was found to be 12:5. Clustering of the cases was found around the age of 60 years and was significantly more common among females in comparison to males. Cases with subclinical thyroid dysfunction were managed by follow up after a thorough evaluation and treatment of other comorbid conditions. Conclusions: The study provides valuable insight towards understanding the epidemiology and management of subclinical thyroid disorders in the present scenario. Screening is recommended for a high-risk population since there is good evidence that subclinical thyroid dysfunctions may be associated with progression to overt disease in up to 5% of the population.
Authors and Affiliations
Suhail Bin Ahmed, Ather Akhtar Pasha, Yogita Singh Thakur
Keywords
Related Articles
- EP ID EP412181
- DOI -
- Views 116
- Downloads 0
A comparative study of methods of Pneumocystis Jiroveci pneumonia in HIV patients with CD4 count less than 200 and the clinical outcome in tertiary care hospital
Background: Pneumocystosis is an opportunistic fungal infection of the respiratory system leading to interstitial plasma cell pneumonia, caused by a taxonomically unique fungus Pneumocystis jiroveci. Major developmental...
Comparison of I-gel and ProSeal laryngeal mask airway during volume controlled ventilation
Introduction: I-gel and the ProSeal laryngeal mask airway (PLMA) are two supra-glottic airway devices with gastric channel used for airway maintenance in anesthesia. This study was designed to evaluate the efficacy of I-...
A Study to Evaluate the Effect of Neo-adjuvant Chemotherapy on Hormonal and Her-2 Receptor Status in Carcinoma Breast
Background: The advances in diagnosis and treatment, in the management of breast cancer have led to excellent cure rates for tumors detected in early stage. Even patients with stage III disease have 5 years survival rat...
Social accountability - The missing link in dental education
In this century, dental colleges will be gauged by their capacity to anticipate the kind of doctors required by evolving health systems. They will need to consider the challenges these systems face as they grapple with c...
Prevalence of microbial infection and strategic pattern of antimicrobial resistance among intensive care unit patients in a tertiary care teaching hospital from rural Northern India
Background: Better management of patients cannot be ensured and the antibiotic policy cannot be designed till one knows the profile of prevalent strains along with their antimicrobial resistance pattern. Objective: To as...