Increased frequency of hla-drb1*12 in asthma patients visiting a teaching hospital Lahore, Pakistan
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH - Year 2015, Vol 7, Issue 4
Abstract
Background: Throughout the world, there are more than 300 million people of asthma and its prevalence in Pakistan is 3.7%. In Pakistan, there are studies on association of HLA with different diseases but data about HLA association with bronchial asthma is limited. An Iranian study described increased frequency of DRB1*12 allele in asthmatic patients. Therefore, present study was designed to determine frequency of HLA-DRB1*12 allele in patients of bronchial asthma. Material and Method: Fifty clinically-diagnosed bronchial asthma patients between 18-40 years with the history of allergy and 30 healthy subjects were selected. HLA-DRB1*12 allele and total serum IgE level was determined by PCR and ELISA technique respectively. Student-t test was applied to observe group mean difference. A p-value of ≤0.05 was considered statistically significant. Results: Frequency of HLA-DRB1*12 allele in asthma patients was high (42%) compared to controls (20%) and on comparison there was statistically significant difference (p=0.04). Mean ± SD of total serum IgE level of bronchial asthma patients was high (861.6 ± 559.2 IU/ml) compared to controls (204.7 ± 237 IU/ml) and on comparison there was statistically significant difference (p = <0.001). Mean ±SD of total IgE level in HLA-DR B1*12 positive asthma patients was high (607.9 IU/ml) compared to HLA-DR B1*12 negative asthma patients (518.4 IU.ml) and on comparison there was no significant difference. Conclusion: Frequency of HLA-DRB1*12 was increased in bronchial asthma patients but this allele did not confer susceptibility to the raised total serum IgE levels.
Authors and Affiliations
Khursheed Javed, Nadeem Afzal, Faheem Shahzad, Saba Khaliq, Shah Jahan,, Saleem-u- Zaman, Waqas Latif, Shaguftta Khalid
Keywords
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