Increased plasma total ghrelin levels in patients with chronic renal failure: comparison with healthy subjects and relationship with hemodynamic parameters

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Increased plasma total ghrelin levels in patients with chronic renal failure:<br /> comparison with healthy subjects and relationship with hemodynamic parameters

Journal Title: Αρχεία Ελληνικής Ιατρικής - Year 2005, Vol 22, Issue 4

Abstract

OBJECTIVE Ghrelin is an orexigenic peptide identified in the stomach as a ligand for the growth hormone secretagogue-receptor. The effect of renal function on plasma ghrelin levels is little known. Recent studies have shown that ghrelin has important hemodynamic effects. The aim of this cross-sectional study was to investigate differences in plasma ghrelin levels between patients with chronic renal failure (CRF) and healthy subjects and explore the relationship between plasma ghrelin levels and indices of left ventricular function. METHOD Fasting plasma total ghrelin levels in 122 patients with CRF (57 on hemodialysis and 65 not on hemodialysis) were compared with those of 57 control subjects. Indices of left ventricular systolic and diastolic function, left ventricular mass and myocardial performance index were measured using M-mode and Doppler echocardiography. RESULTS Mean (95% CI) plasma total ghrelin levels were higher in patients with CRF than in controls: 4,620.4 (4,305.2-4,935.8) vs 1,998.6 (1,674.6-2,322.6) pg/mL (age-adjusted P

Authors and Affiliations

D. DOULGERAKIS, N. TENTOLOURIS, K. MAKRILAKIS, I. MOYSSAKIS, A. KOKKINOS, C. GEORGOULIAS

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