Increased prevalence of ANA and Anti-SSA in African American rheumatoid arthritis patients is not associated with increased serum chemokine concentrations
Journal Title: International Journal of Clinical Rheumatology - Year 2017, Vol 12, Issue 5
Abstract
Background: African American (AA) rheumatoid arthritis (RA) patients have increased disease activity compared to Caucasian (CAU) RA patients. Serum chemokines, such as CXCL10, are increased in RA patients and may function as markers of disease activity. The aim of this study was to compare autoantibody seropositivity in AA and CAU RA patients and analyze the link between antibody positivity and serum chemokine concentration. Methods and Findings: 93 AA RA patients and 93 CAU patients from the University of Pittsburgh cohort of RA patients were matched using a propensity model with race as the outcome and age, gender, body mass index (BMI), disease duration, anti-tumor necrosis factor (TNF) use, rheumatoid factor (RF) positivity, and cyclic citrullinated peptide (CCP) positivity as the predictor variables in a logistic regression. Plasma from the matched subjects was analyzed for autoantibodies including antinuclear antibody (ANA), anti-Sjogren's syndrome-related Antigen A (SSA), and anti-Sjogren's syndromerelated Antigen B (SSB). To evaluate differences in serum chemokine concentrations, anti-SSA positive samples were matched with anti-SSA negative samples for age, gender, disease duration, RF positivity, and CCP positivity using a propensity model. CXCL10 was measured using an ELISA assay. Anti-SSA was more prevalent in AA RA patients compared to CAU RA patients (11.70% vs. 3.23%; p=0.02). ANA was more prevalent in AA RA patients (21.28% vs. 10.75%; p=0.04). A total of 14 patients (7.57%) were anti-SSA positive. Anti-SSA positivity was not associated with increased serum CXCL10 levels compared to the anti-SSA negative group. RF positivity was associated with an increased serum CXCL10 concentration compared to the RF negative group (253.14 vs 153.46 pg/ml). Conclusions: AA RA patients have an increased prevalence of anti-SSA and ANA compared to CAU RA patients, which may be contributing to the increased disease activity seen in this population via a mechanism outside of the CXCL10 chemokine pathway.
Authors and Affiliations
Tyler J. Sevco, Doug P. Landsittel, Chengli Shen, Larry W Moreland
Keywords
Related Articles
- EP ID EP603708
- DOI -
- Views 53
- Downloads 0
Development of lymphoma in patients with primary Sjögren syndromes
Background: Lymphoma is the main complication of primary Sjögren syndrome (pSS). The aim of this study was to describe the prevalence and incidence rate of lymphoma in patients with pSS in eleven centers in Argentina. To...
Subcutaneous panniculitis-like T cell lymphoma in a patient with juvenile idiopathic arthritis treated with Abatacept
Subcutaneous panniculitis-like T-cell Lymphoma (SPTL) is a rare extranodal lymphoma that accounts for less than 1% of all Non-Hodgkin Lymphomas. We describe SPTL in a patient with Juvenile Idiopathic Arthritis (JIA) rece...
The effect of hydroxychloroquine on endothelial dysfunction in patients with rheumatoid arthritis: A doubleblind randomized clinical trial
Aim: The aim of this study was to evaluate the effect of hydroxychloroquine on endothelial dysfunction in rheumatoid arthritis patients by measuring soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble E-Selec...
Influence of single nucleotide polymorphisms on the efficacy of platelet-rich plasma in the treatment of injuries
Tissue repair in musculoskeletal injuries is often a slow and sometimes incomplete process. Musculoskeletal injuries have a great impact on athletes’ especially elite athletes – and a rapid recovery of full efficiency an...
Increased prevalence of ANA and Anti-SSA in African American rheumatoid arthritis patients is not associated with increased serum chemokine concentrations
Background: African American (AA) rheumatoid arthritis (RA) patients have increased disease activity compared to Caucasian (CAU) RA patients. Serum chemokines, such as CXCL10, are increased in RA patients and may functio...