Increased Th17 and reduced Treg cells in patients with unexplained recurrent spontaneous abortion
Journal Title: Clinical and Experimental Obstetrics & Gynecology - Year 2019, Vol 46, Issue 3
Abstract
Immune imbalance of T cells in the maternal-fetal interface is reported to be associated with unexplained recurrent spontaneous abortion (URSA), such as Th17/Tregs/Th1/Th2 cell. The authors’ previous finding demonstrated that the percentage of Th1 cells was higher in the decidual tissues of patients with URSA. However, whether Th17 and Treg cells are altered in URSA remains unknown. In this study, the authors measured the percentage of Th17 and Treg cells by flow cytometry in 30 URSA patients and 30 normal pregnant women. They found that there were a higher proportion of Th17 and a lower number of Treg cells in the decidual tissue of URSA compared to those in normal controls. In conclusion, the results indicate that the changes in the proportion of Th17 and Treg cells in the maternal-fetal interface may be related to the occurrence of URSA.
Authors and Affiliations
Y. Gao, P. Wang, T. Zou, Z. Zhang, W. Liang
Keywords
Related Articles
- EP ID EP622875
- DOI 10.12891/ceog4859.2019
- Views 67
- Downloads 0
Unilateral hydrosalpinx is more likely to be associated with negative Igg chlamydia antibodies and bilateral hydrosalpinges more likely to be associated with positive levels
Purpose: To determine if previous exposure to chlamydia, as evidenced by positive serology, is associated with a greater degree of detectable hydrosalpinges, and to determine if positive serology is more associated with...
Impaired serum thiol/disulphide homeostasis may be another explanation for the pathogenesis of missed abortion
Aim: Oxidative stress is an important factor in pregnancy physiology and embryogenesis. Placental oxidative stress results from deficient trophoblast invasion found to be a cause of a spectrum of disorders including misc...
Hormone therapy is not associated to pain thresholds in healthy postmenopausal women
Purpose of Investigation: To evaluate if hormone replacement therapy modifies pain thresholds in healthy postmenopausal women. Study Design: A cross-sectional study including 78 healthy postmenopausal women. Materials an...
Does maternal age at childbirth and parity have any effect on hearing loss? The 2008-2012 Korean National Health and Nutrition Examination Survey
Objective: This study aimed to assess hearing loss according to maternal age at childbirth and parity. Materials and Methods: The data used in this study were obtained from the 2008-2012 Korean National Health and Nutrit...
Myomectomy over the age of forty
Purpose of investigation: The aim of this study is to evaluate the fertility results of women who had myomectomy surgery in their forties for fertility preservation. Materials and Methods: All women who had myomectomy su...