Indoleamine 2,3-Dioxygenase (IDO); Silenced Dendritic Cell Vaccine with Ipilimumab in Treating Metastatic Melanoma Patients: A Case Report
Journal Title: Journal of Clinical & Cellular Immunology - Year 2023, Vol 14, Issue 3
Abstract
Immunotherapy has revolutionized the treatment landscape for metastatic melanoma. This case report presents the clinical course of a patient with metastatic melanoma who received combination therapy with ipilimumab, a CTLA-4 checkpoint inhibitor, and an Indoleamine 2,3-Dioxygenase (IDO)-silenced Dendritic Cell (DC) vaccine. The treatment approach aimed to enhance antitumour immunity by blocking immune checkpoints and activating dendritic cells. The patient demonstrated a significant clinical response, indicating the diversification and potentiation of the antitumour effects. This case underscores the potential of combined immunotherapeutic strategies in achieving durable and robust antitumour effects.
Authors and Affiliations
Qing Chen Wang Liu Zhongbin Zhoa
Keywords
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- EP ID EP741782
- DOI 10.35248/2155-9899.23.14.688
- Views 32
- Downloads 0
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