Indoleamine 2,3-Dioxygenase (IDO); Silenced Dendritic Cell Vaccine with Ipilimumab in Treating Metastatic Melanoma Patients: A Case Report
Journal Title: Journal of Clinical & Cellular Immunology - Year 2023, Vol 14, Issue 3
Abstract
Immunotherapy has revolutionized the treatment landscape for metastatic melanoma. This case report presents the clinical course of a patient with metastatic melanoma who received combination therapy with ipilimumab, a CTLA-4 checkpoint inhibitor, and an Indoleamine 2,3-Dioxygenase (IDO)-silenced Dendritic Cell (DC) vaccine. The treatment approach aimed to enhance antitumour immunity by blocking immune checkpoints and activating dendritic cells. The patient demonstrated a significant clinical response, indicating the diversification and potentiation of the antitumour effects. This case underscores the potential of combined immunotherapeutic strategies in achieving durable and robust antitumour effects.
Authors and Affiliations
Qing Chen Wang Liu Zhongbin Zhoa
Keywords
Related Articles
- EP ID EP741782
- DOI 10.35248/2155-9899.23.14.688
- Views 20
- Downloads 0
The Pattern of CD4+ T Cell Recovery and Determinants of HIV Infected Individuals Receiving Highly Active Antiretroviral Treatment in Mekelle Hospital, Tigray Northern Ethiopia: A Retrospective Study
Background: With the development of antiretroviral treatment, the incidence of HIV-related illness and death has significantly decreased. Nevertheless, some individuals living with HIV who are taking Anti-Retroviral Ther...
Hotairm1 Controls S100A9 Protein Phosphorylation in Myeloid-Derived Suppressor Cells during Sepsis
During the acute phase of sepsis, the S100A9 proinflammatory protein resides in the cytosol in a phosphorylated form. In contrast, S100A9 relocalizes to the nucleus in an unphosphorylated form during the late/chronic sep...
Indoleamine 2,3-Dioxygenase (IDO); Silenced Dendritic Cell Vaccine with Ipilimumab in Treating Metastatic Melanoma Patients: A Case Report
Immunotherapy has revolutionized the treatment landscape for metastatic melanoma. This case report presents the clinical course of a patient with metastatic melanoma who received combination therapy with ipilimumab, a CT...
Assessing the Fidelity of the Malaria Vaccine Implementation in Malawi
Globally, remarkable progress has been made in the fight against malaria over the last two decades, yet the rate of reduction of malaria case incidence and mortality seems stalled. Globally, malaria case incidence (i.e.,...
Exercise-Mediated Immune Protection in Chronic Kidney Disease Decreases Infection and Severe Evolution of COVID-19
It is constantly sought to understand the different mechanisms of action of the immune system to establish potential efficient therapeutic targets for different clinical situations. Thus, the present study aims to expand...