Induced pluripotent stem (iPS) cells in domestic animals − recent achievements − a review
Journal Title: Animal Science Papers and Reports - Year 2013, Vol 31, Issue 2
Abstract
Pluripotent cells show the unlimited self-renewal capacity and the potential to differentiate into the cell lineages originating from three germ layers. To date real pluripotent stem cell lines, able to generate germ line chimeras, have been established in rodents. Large domestic animals, especially pig, due to their considerable anatomical and physiological similarities with humans are thought to be convenient model to test potential of pluripotent cells in cell replacement therapy before their clinical use. However, creating pluripotent cells in domestic animals until now has met the limitations due to lack of evidence for germ line contribution. Therefore they can not be considered real pluripotent cells but rather putative embryonic or embryonic-like stem cells. Recently, much attention has been drawn to the reprogramming technologies which enable redirection of differentiated somatic cells to the pluripotent status. The aim of this review is to present the recent achievements in generating of induced pluripotent stem (iPS) cells in domestic animals.
Authors and Affiliations
Ewa Chronowska
Keywords
Related Articles
- EP ID EP70614
- DOI -
- Views 150
- Downloads 0
Bovine mammary stem cells studies – current status – a review
Bovine mammary gland is a unique organ with regard to its frequently repeating cycles of growth and involution throughout the life of an animal. In literature there is only scarce information concerning development of it...
Evaluation of anesthesia and reproductive performance upon diazepam and xylazine injection in rats
The aims of the current study were to evaluate the effects of diazepam (D) and/or xylazine (X) on the induction of sedation and anesthesia, performing ovarian transplantation and litter size upon administration during pr...
Ascorbic acid or pyruvate counteracts peroxidative damage in boar sperm cryopreserved with or without α-tocopherol
Ejaculates of four crossbred boars were frozen with or without 200 μg/mL of α-tocopherol. Frozen samples were then thawed in the extender containing either ascorbic acid (2.5, 5 or 10 mM) or pyruvate (1 or 5 mM) to obtai...
Relationship between milk yield of cows and their 24-hour walking activity
Despite many genetic and environmental factors, the level of physical activity may be a very good indicator of the physiological (e.g. estrus, approaching parturition) or health status of cows. The aim of this study was...
Effect of dietary mixture of Aspergillus probiotic and selenium nano-particles on growth, nutrient digestibilities, selected blood parameters and muscle fatty acid profile in broiler chickens
Forty five chickens (15 days old) were assigned to three groups: (1) control group fed a basal diet; group (2) fed the basal diet supplemented with 0.05% Aspergillus awamori and group (3) fed mixture of A. awamori 0.05%...