INDUCTION OF LABOUR WITH VAGINAL MISOPROSTOL IN INTRAUTERINE FOETAL DEATH
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 89
Abstract
BACKGROUND Intrauterine foetal death is an unfortunate event met in obstetric practice. Misoprostol has emerged as an efficient and relatively safe drug to deliver the baby in this condition. The objective of this study is to evaluate the safety and efficacy of vaginal misoprostol tablets for the induction of labour in intrauterine foetal death. MATERIALS AND METHODS This uncontrolled clinical trial was performed on 100 women with intrauterine foetal death from January 2016 to December 2016 at Silchar Medical College and Hospital. All women were properly evaluated. Informed consent was taken and vaginal misoprostol tablets at a dose of 50 mcg 4 hourly was used to induce labour. The results were assessed. RESULTS In a study of 100 women, mean natural age was 26.21 ± 4.98 years, mean gestational age was 38.81 ± 4.26 weeks, 61% women were primigravida and the rest were multigravida; 80% were booked cases, 72% belonged to rural areas and 76% were illiterates. The mean initial Bishop’s score was 2.23 ± 1.82 (range 0 to 6), while following induction with misoprostol the mean Bishop’s score was 6.98 ± 2.1, the mean difference was 4.75. P value was statistically significant. The mean induction-labour onset interval was 10 ± 6.65 hours and the mean induction-delivery interval was 13.60 hours with 46.46% women delivering within 12 hours. The mean misoprostol dose required was 152.5 ± 88.5 mcg. Induction was successful in all women, but laparotomy was needed in 1 women because of uterine rupture. The side effects noted were nausea (7%), vomiting (2%), diarrhoea (4%), fever (5%), uterine hyperstimulation (4%), ruptured uterus (1%), retained placenta (3%) and atonic post-partum haemorrhage (3%). CONCLUSION Misoprostol is an effective, economic and safe drug that can be used for cervical ripening and labour induction in intrauterine foetal death. Clinical significance- the response to misoprostol is influenced by the gestational age, Bishop’s score and parity of the women.
Authors and Affiliations
Neeta Sarma
Keywords
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- EP ID EP277943
- DOI 10.14260/jemds/2017/1346
- Views 78
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