Infections by Staphylococcus aureus: a rising threat and a major clinical challenge! Prevalence and Antibiogram of S.aureus isolated from various clinical samples received in a tertiary care hospital in Central India, with special reference to MRSA
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 2
Abstract
Introduction: MRSA infections have been increasing in Indian hospital ICU’s and wards many of which are resistant to antibiotic treatment. Aim: To study the prevalence of MRSA and antibiotic resistance pattern in Staphylococcus aureus from various clinical samples in tertiary care hospital, in central India Materials & Methods: A total of 2660 samples received in the Microbiology Laboratory over a period of 3 months. 1320 were from in-patients department. Out of these 772 samples were culture positive. Among these, 215 were Staphylococcus aureus, and included in the study, while all others were excluded. Standard biochemical tests were used for identification of S.aureus. The MRSA strains were identified by using Cefoxitin 30μgdisc on Muller Hinton agar and antibiotic susceptibility testing was done by Kirby-Bauer disc diffusion and zones of inhibition interpreted as per CLSI 2017 guidelines. Results: Out of the total of 772 culture positive samples, Staphylococcus aureus was isolated in 215 samples. A total of 90 isolates (41%) were from blood, 80 (37%) from pus and wound swab, 32(14.9%) from ear discharge, 8 (3.7%) from respiratory and 5 (2.3%) were from CSF. Most isolates were resistant to Penicillin and Ampicillin (96.7% & 94.9% respectively), while 62% isolates were resistant to Ciprofloxacin, 70% to Erythromycin, 54% to Clindamycin, and 60% to Gentamycin. All the isolates were sensitive to Teicoplanin i.e no isolates were found to be resistant and 99 % isolates were sensitive to Linezolid. Among the 215S.aureus isolates, 115 (53%) were MRSA. Conclusion: This study documents drug resistant patterns in S.aureus and the high prevalence of MRSA strains among hospital patients. It emphasises the need for prompt and effective measures required to limit the spread drug resistant pathogens and MRSA strains by use ofappropriate antibiotic selection and effective infection control practices .
Authors and Affiliations
Purohit Manish
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