Influence of anticoagulant therapy in assessment of Fibrinolysis activity in post acute myocardial infarction patients
Journal Title: Scholars Academic Journal of Pharmacy - Year 2016, Vol 5, Issue 1
Abstract
Acute myocardial infarction is a serious disease in which a patient can survive or die depending on his or her attitude towards life, myocardial infarction, commonly known as a heart attack, is the irreversible necrosis of heart muscle secondary to prolonged ischemia. Morbidity and mortality from myocardial infarction are significantly reduced if patients and bystanders recognize symptoms early, activate the emergency medical service (EMS) system, and thereby shorten the time to definitive treatment. The goal of antithrombotic therapy (the combination of anticoagulant and antiplatelet therapy) is to prevent clot extension and clot reformation in cases where the clot has undergone fibrinolysis either by intrinsic mechanisms, fibrinolytic treatment, or mechanical means .This is a descriptive analytical case control study aimed to evaluate the effect of anticoagulants therapy( heparin and warfarin ) in D-dimer, PT, INR and PTT level among patients with acute myocardial infarction conducted in Sudan cardiac center hospital. Thirty patients after MI and twenty normal controls have been studied. Both male and female of different ages and different duration of disease from first day above to thirty day .The MI patients also include co-exist disease diabetes and hypertension, they received different Anticoagulants therapy. The results of PTT in patients in mean were (31.65 second) and the mean of PTT results in control were (32.71 seconds) demonstrated in table (2) the results of D-Dimer in patient in mean were ( 2264 ng/ml) and the mean of D-Dimer results in control (145.6ng/ml) demonstrated in table. In this study, we found a statistically significant superiority of warfarin in combination with aspirin (relative risk reduction, 29 percent) as well as of warfarin alone relative risk reduction, 19 percent) as compared with aspirin for the reduction in the composite end point. Keywords: Post Myocardial infarction, Anticoagulant therapy, fibrinolysis activity.
Authors and Affiliations
Nada Mohammed Ahmed Ali, Fath Elrahman Mahdi Hassan Gameel, Mohieldin Elsayid
Keywords
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