Influence of astemizole, an H1 receptor antagonist, on the locomotors activity of carbamazepine and valproate in mice
Journal Title: Current Issues in Pharmacy and Medical Sciences - Year 2012, Vol 25, Issue 2
Abstract
In the present study, we examined the influence of the second generation H1 receptor antagonist, astemizole, co-administered with carbamazepine and valproate on the exploratory and spontaneous activities in mice. Locomotor activity was monitored electronically using a Digiscan system with relation to the ambulatory and rearing activities, as well as, total distance traveled by animals within two 15-min periods. Results indicated that astemizole given alone did not affect on the three variable of motor activity, i.e. horizontal activity, total distance or vertical activity in mice. However, this H1 receptor antagonist significantly worsened horizontal and vertical activity of mice when was co-administered with valproate or carbamazepine in exploratory time. Moreover, it decreased total distance in combination with carbamazepine evaluated in spontaneous time. Our data clearly indicated that even newer generation of histamine receptor antagonists should be used with caution in patients suffering on epilepsy. It should be stressed that combined treatment of astemizole with carbamazepine or valproate may be clinically hazardous.
Authors and Affiliations
Mariusz Świąder, Katarzyna Świąder
Keywords
Related Articles
- EP ID EP153049
- DOI -
- Views 82
- Downloads 0
The improvement of treatment efficacy of gastropathy associated with the use of nonsteroidal anti-inflammatory drugs in Helicobacter pylori-negative patients with osteoarthritis
Among the more common side effects of osteoarthritis treatment are NSAID-gastropathy and NSAID-enteropathy. NSAIDs can cause direct injury to colon tissue and also impair synthesis of prostaglandins, reduce mucosal integ...
Effect of combinational arginase and canavanine treatment on normal human peripheral blood lymphocytes in vitro
Recombinant human arginase (rhARG)-based therapy to restrict arginine availability for malignant cells is a promising strategy to treat some cancers, including those of hematological origin. In the present study, we eval...
Multiple sclerosis – epidemiology, diagnosis, treatment and rehabilitation - a literature review
At present, multiple sclerosis is regarded as disease in which the immune system fights its own cells, in this case the nervous tissue. The World Health Organisation (WHO) estimates that 2.5 million people in the world s...
Photostability of triazole antifungal drugs in the solid state
The publication is devoted to photostability assessment of four triazole antifungal drugs: fluconazole, itraconazole, posaconazole and voriconazole. The compounds were exposed in the solid state using the whole spectrum...
A botanical and pharmacological description of petasites species
The objective of this review was to evaluate the botanical and pharmacological description of Petasites species. Petasides (butterbur) as a perennial shrub which was found in Europe and also in a parts of Asia and North...