Influence of Derivatization on Molecular and Pharmacokinetic Properties of Phenoxy Acids – An In Silico Study
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2016, Vol 2, Issue 12
Abstract
Abstract: Molecular and pharmacokinetic properties prediction is important determinant in the current drug development process. In this study, molecular and pharmacokinetic properties of phenoxy acids and their derivatives are theoretically predicted using in silico tools to determine how synthetic modifications such as branching, amidation, esterification, heterocyclic groups, and hydrazide group change the structural and pharmacokinetic properties with respect to the parent phenoxy acid. From the results it was observed that phenoxy acid possess good central nervous system (CNS) permeability compared to the acid derivatives. It could also be further predicted that conversion of phenoxy acid to functional derivatives leads to molecules with good pharmacokinetic profile. Based upon these theoretical predictions, it can be concluded that various chemical modifications of phenoxy acid moiety furnish promising derivatives with good pharmacokinetic profile and oral bioavailability. Keywords: Phenoxy acids, preADME, Molinspiration
Authors and Affiliations
Swapna. B, Shaheen Begum, Arifa Begum, Sujatha. D, Bharathi K
Keywords
Related Articles
- EP ID EP389161
- DOI -
- Views 108
- Downloads 0
Nurses Knowledge and Practices Toward Pressure Ulcer Prevention In General Hospital Lahore
Abstract: Pressure ulcer lead to pain and discomfort for patients and also cause prolong illness, delay restoration, increase patient’s hospital stay, and may lead to infirmity and even death. The purpose of this study w...
Factors That Influences on Standard Precautions among Nurses in Tertiary Hospital Lahore Pakistan
Abstract: Employing standard precautions means taking precautions with everybody. If precautions are taken with everyone, health care workers do not have to make assumptions about people's lifestyles and risk of infectio...
Determination of Blood Levels of Lead in Pregnant Women in Nnewi, Anambra State, South Eastern Nigeria
Lead is a well known environmental and reproductive toxicant. This study was designed to evaluate the blood lead levels in pregnant women in Nnewi, Anambra State, South Eastern Nigeria. A total of 100 apparently healthy...
Acute pancreatitis following multiple wasps stung
Abstract: Wasp stings are not uncommon worldwide. In developed countries people are affected by one or few stings. Commonly cause self-limiting local reaction. Infrequently more serious systemic reactions such as anaphyl...
Predict How Somatoform Disorder Patients Can Expand Their Coping Strategies for Dealing with Difficult Challenges in Life
Abstract: We have two ways for coping: the way of avoidance or the way of acceptance. The present study aimed to determine the most adaptable coping strategies of patients with diagnosed somatoform disorder. Along with,...