Influence of Derivatization on Molecular and Pharmacokinetic Properties of Phenoxy Acids – An In Silico Study
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2016, Vol 2, Issue 12
Abstract
Abstract: Molecular and pharmacokinetic properties prediction is important determinant in the current drug development process. In this study, molecular and pharmacokinetic properties of phenoxy acids and their derivatives are theoretically predicted using in silico tools to determine how synthetic modifications such as branching, amidation, esterification, heterocyclic groups, and hydrazide group change the structural and pharmacokinetic properties with respect to the parent phenoxy acid. From the results it was observed that phenoxy acid possess good central nervous system (CNS) permeability compared to the acid derivatives. It could also be further predicted that conversion of phenoxy acid to functional derivatives leads to molecules with good pharmacokinetic profile. Based upon these theoretical predictions, it can be concluded that various chemical modifications of phenoxy acid moiety furnish promising derivatives with good pharmacokinetic profile and oral bioavailability. Keywords: Phenoxy acids, preADME, Molinspiration
Authors and Affiliations
Swapna. B, Shaheen Begum, Arifa Begum, Sujatha. D, Bharathi K
Keywords
Related Articles
- EP ID EP389161
- DOI -
- Views 138
- Downloads 0
A Cross-Sectional Study on Socio- Demographic, Behavioural& Clinical Profile of Adult Male People Living With HIV/AIDS Attending In A Tertiary Hospital of Kolkata, India
Abstract:HIV/AIDS is a serious challenge for the developing as well as the developed world. Globally, 35.0 million (33.2–37.2 million) people were living with HIV at the end of 2013. [1] Although many HIV‑infected indivi...
Topical Medications and Dosage Specificity: Somatotype and Anatomical Body Girths as Correlates and Predictors of Finger Tip Units Metric Length
Abstract: Finger Tip Unit (FTU) is being considered as a means of quantifying dosages but rough guides are provided in literature and it is without psychometric value. The primary aims of this study were to determine ref...
Measurement of Bisphenol-A in Human Urine by Ultra-Performance Liquid Chromatography/Tandem Mass Spectrometry
Abstract: A simple and rapid ultra-performance liquid chromatographic tandem mass spectrometric assay for the measurement of bisphenol-A (BPA) in human urine was developed and validated. Sample preparation involved addit...
Self-Reported Knowledge and Attitude of Emergency Physicians and Residents Regarding Preparedness for Radiological Emergencies in the Aseer Region, Kingdom of Saudi Arabia
Abstract: Radiological accident can have a huge impact on public health. Emergency physicians should be prepared to respond to potential radiation emergencies by improving their knowledge and attitude regarding radiation...
Knowledge, Attitude & Practices Related To Prevention of Mosquito Born Diseases in Rural Area of Lahore
According to World Health Organization, Mosquito borne diseases are the fast emerging viral diseases in many areas of the world. Mosquito borne diseases affects in the tropical and sub tropical regions in the world (Arun...