Influence of Diallyldisulphide on Glycogen Breakdown in Alloxan Diabetic Liver
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 3
Abstract
Diabetes mellitus is chronic metabolic disorder of glucose metabolism in particular due to deficiency of insulin. The glycogen formation as well as glucose utilization are profoundly affected in diabetes mellitus. Diallyldisulphide (DADS), an important disulphide of garlic oil, is known to improve glycemic conditions in diabetic animals, but its specific action on glycogen metabolism is not well understood. Hence a study was undertaken to assess the effects of DADS on liver glycogenolysis in alloxan diabetic rats. The alloxan diabetic liver slices were incubated with DADS(4mg/g liver tissue) and the glycogen breakdown was studied. The results indicate that glycogen formation as well as glycogen breakdown in alloxan diabetic liver is significantly decreased and DADS shows a stimulatory effect on glycogen breakdown in alloxan diabetic liver.
Authors and Affiliations
Prashanthkumar Goudappala, Ethirajan Sukumar, Kashinath R T
Keywords
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- EP ID EP594694
- DOI 10.9790/0853-1603043032
- Views 81
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