Influence of dioxin intoxication on the human system and possibilities of limiting its negative effects on the environment and living organisms
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2014, Vol 21, Issue 3
Abstract
[b]Introduction and objective[/b]. Despite the restrictive legal regulations related to the reduction of dioxins emission, their concentration in the environment is still too high. Mainly, this is related to the illegal utilisation of electronic equipment and combustion of wastes, and also to intensified activity and maintenance of ships, especially in developing countries. The most important remaining source in Europe is the metal industry. Studies on the mechanism of impact of dioxins are still being carried out. This review points at new possibilities for limiting the molecular mechanisms of dioxins activity, inter alia, through the application of high doses of tocopherol and acetylsalicylic acid while treating dioxins intoxication. [b]Brief description of the state of knowledge. [/b]Apart from the knowledge of dioxins affinity to the aryl hydrocarbon receptor (AhR), the multi-stage radical-form actions and the pro-inflammatory mechanism associated with cyclooxygenase-II enzyme (COX-2) are under intense investigation at the moment. Due to the high affinity of dioxins to animals adipose tissue and their ability to accumulate in it, they can enter the food chain. Furthermore, high dioxin doses can cause poisoning manifested as advanced clinical symptoms, whereas in smaller doses, when cumulated, can cause metabolic changes which are often difficult to associate with their presence. Recently, some serious food contaminations by dioxins have been demonstrated. Sea fish and products from contaminated aqueducts still constitute potential sources of dioxins pollution. [b]Conclusion.[/b] According to recent studies, dioxins are present in different concentrations in the environment and cause specific and long-time effects. These effects could be limited by the use of tocopherol and acetylsalicylic acid.
Authors and Affiliations
Ireneusz Całkosiński, Joanna Rosińczuk-Tonderys, Justyna Bazan, Maciej Dobrzyński, Agnieszka Bronowicka-Szydełko, Katarzyna Dzierzba
Keywords
Related Articles
- EP ID EP80828
- DOI -
- Views 127
- Downloads 0
Intensification of anxiety and depression, and personal resources among women during the peri-operative period
Aim. Surgical treatment of women due to gynaecological disorders is the cause of stress and may lead to psychological changes. Studies concerning human response to stress emphasize the importance of the effect of the lev...
Risk of Lyme disease at various sites and workplaces of forestry workers in eastern Poland
Knowledge about the seasonal activity of various stages of the[i] Ixodes ricinus [/i]tick is of great importance while developing models of the circulation of pathogens transmitted by ticks in a given environment, as wel...
<strong>Acute respiratory distress syndrome (ARDS) complicating influenza <em>A/H1N1v</em> infection - a clinical approach.</strong>
ARDS is defined as an acute inflammatory syndrome characterized with bilateral parenchymal lung infiltrates on chest radiograph and PaO[sub]2[/sub]/FiO[sub]2[/sub] ratio&amp;lt;200 resulting from causes other than ac...
Harmonisation of standards related to limiting chemical risk associated with work processes
The presented paper tackles the issue of risk factors specific to work processes that involve the presence of chemicals. The reason that supports the present approach is the fact that the risks most likely to affect heal...
Antigenic and allergenic properties of Amaranthus Spinosus pollen--a commonly growing weed in India.
Amaranthus spinosus (Fam. Amaranthaceae) is an important aeroallergen in India and grows commonly in different parts of the country. In spite of its clinical significance in Type I hypersensitivity disorders, the antigen...