Influence of extract of peach ordinary (persica vulgaris) leaves on the state of thymic-lymphatic element of the immune system of rats in conditions of chronic immobilization stress
Journal Title: ScienceRise: Pharmaceutical Science - Year 2018, Vol 0, Issue 3
Abstract
<p><strong>The aim</strong> – study of the influence of thick extract of peach ordinary (Persica vulgaris) leaves (TEPL) on the state of thymic-lymphatic element of the immune system of rats in conditions of chronic immobilization stress.</p><p><strong>Materials and methods.</strong> The model of chronic immobilization stress was reproduced for 18 days by daily four hour immobilization of rats in tight box. Investigated TEPL, which was obtained at the Department of Chemistry of Natural Compounds of National University of Pharmacy from peach leaves of the Salve variety harvested in Tajikistan was administered intragastrically in a conditionally effective dose of 100 mg/kg. Reference drug the syrup «Immuno-Ton» was used in a dose of 3 ml/kg.<strong> </strong>The state of thymic-lymphatic element of the immune system in conditions of chronic immobilization stress was determined after the euthanasia of animals under mild inhalation anesthesia by the results of the study of the coefficients of thymus and spleen mass and histological studies on micropreparations, which were prepared according to the generally accepted method. To assess the nature of the effect of the TEPL on the condition of the organs of the rat thymic-lymphatic system under chronic immobilization stress conditions, a comparison was made with intact control and control pathology.</p><p><strong>Results.</strong> It was determined that chronic immobilization stress had suppressive effect on the thymic-lymphatic element of the immune system. An increase in the width of the marginal zone of lymphoid follicles and muft and the number of perivascular lymphatic clusters 1.2 times (p <0.05) compared with control pathology, reduction of signs of stressful hypoxia - the number of structures of white pulp with spasm of the central arteries was noted in the spleen. Reducing the degree of change from the third to fourth phase to the first phase of the accident transformation is set in the thymus, which is confirmed by an increase in the mass of the thymus mass by 2.7% in comparison with the control pathology.</p><p><strong>Conclusions.</strong> The ability of TEPL to restore impaired activity of organs of thymic-lymphatic element of the immune system has been proved. It is likely, that polyphenolic compounds of TEPL exhibit antioxidant properties, enhancing the activity of the antioxidant system, and polysaccharides exhibit immunostimulative properties, the result of which is a stressprotective action. The effectiveness of TEPL was not inferior to the reference drug «Immuno-Ton»</p>
Authors and Affiliations
Oksana Mishchenko, Ganna Zaychenko, Churshed Sharifov, Оlena Koshova, Julia Larianovskaya, Olena Khalieieva
Keywords
Related Articles
- EP ID EP526834
- DOI 10.15587/2519-4852.2018.135748
- Views 152
- Downloads 0
Scientific substantiation of the product range renewal model for manufacturing pharmaceutical enterprise
<p>In modern conditions, aggravation of competition in the national pharmaceutical market, increase in cost of scientific developments and investments in pharmaceutical industry, raising of the level of requirements and...
Substantiation for the optimal strategy of risk management in marketing communicative activities of pharmaceutical enterprises based on mathematical model approach
Aim. To develop a mathematical model of risk analysis and evaluation in the marketing communication activity of pharmaceutical manufacturing enterprises in promoting a new medicine product under limiting and (or) saving...
Організація фармацевтичного забезпечення військовослужбовців, які брали участь у бойових діях, на засадах фармацевтичного права
<p>У статті наведено сучасний стан медико-фармацевтичного забезпечення пільгових категорій населення України, до яких чинним законодавством віднесено військовослужбовців, що брали участь у проведенні антитерористичної оп...
Синтез та протимікробна активність амідів 3-бензил-5-метил-4-оксо-2-тіоксо-1,2,3,4-тетрагідротієно[2,3-d]піримідин-6-карбонової кислоти
<p><strong>Мета.</strong> Цілеспрямоване отримання нових протимікробних засобів серед похідних 2-тіотієно[2,3-d]піримідин-6-карбонових кислот.</p><p><strong>Матеріали та методи дослідження.</strong> У роботі використовув...
Identification and quantitative determination of steroidal compounds in the plant material of cabbage
<p>Vegetable crops are inexhaustible source of biologically active compounds. Cabbage (Brassica oleracea L.) – is a plant that has been extensively used in folk medicine of different countries of the world for the treatm...