Influence of IGF-I and IGFBP-3 on bone mineral density in postmenopausal women
Journal Title: Przegląd Menopauzalny - Year 2006, Vol 25, Issue 3
Abstract
Aim of study: Serum concentration of insulin-like growth factor-I (IGF-I) decreases with age but the link between IGF-I and postmenopausal osteoporosis remains controversial. IGFBP-3 is IGF-I binding protein, which prolongs the half-life of IGF-I and serves as metabolic reservoir of IGF-I. The goal of this study was to determine the effect of IGF-I and IGFBP-3 on bone mineral density in postmenopausal women. Materials and methods: The study included sixty-two (62) postmenopausal women, mean age 69.8±8.3 years. All the women were examined in order to exclude any other risk factors of osteoporosis. Results: Bone mineral density (BMD) was measured in the femoral neck, using dual-energy X-ray absorptiometry (DPX, Lunar, USA). The obtained results were evaluated vs. WHO criteria of osteoporosis. IGF-I and IGFBP-3 were measured by RIA (IGF-I Biosource Europe S.A., Belgium; IGFBP-3 Immunotech, France). Serum concentrations of IGF-I and IGFBP-3 were significantly lower in the group of osteoporotic women and correlated positively with BMD of the femoral neck, respectively (r=0.48, p
Authors and Affiliations
Elżbieta Skowrońska-Jóźwiak, Andrzej Lewiński
Keywords
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