INFLUENCE OF LOCALLY APPLIED HEAT ON THE PERFORMANCE OF TRANSDERMAL DICLOFENAC SODIUM PLASTERS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 10
Abstract
Objective: Applied heat to dermatologic preparations influences the medicine’s performance, such as drug release rate and drug absorption. However, there is little information concerning the performance of non-steroid anti-inflammatory drug plasters at high temperature. Therefore, this study aimed to evaluate the effect of heat on drug dissolution and skin permeation from two kinds of Diclofenac sodium (DF) plasters In vitro, as well as transdermal absorption in healthy adult volunteers.Methods: DF dissolution tests were performed using the paddle-over-disk method with 500 mL of phosphate-buffered saline at 32 and 41°C. DF permeation was studied at 32 and 41°C using a Franz-type cell with Yucatan micropig skin (YMP). Moreover, eight healthy volunteers were tested two times for each preparation while receiving a piece of DF plaster, and then the same plaster with a heat-generating pad over 4 hours maintained at 40-41°C; then, the residual amount of DF in the plasters was evaluated.Results: Significant differences in the cumulative amount released from the preparations were seen between 32 and 41°C. The cumulative amount that permeated across YMP skin from all preparations at 32°Cwas also significantly higher than that obtained at 41°C. Furthermore, heat application on the plasters resulted in 1.4-fold higher absorption amount than without heat in the clinical study.Conclusion: This study indicated that locally applied heat caused rapid and substantial drug release, resulting in increased transdermal absorption of DF compared with that upon the use of the plaster without heat.Â
Authors and Affiliations
Ichie Suzuki, Yasunori Miyazaki, Tomonobu Uchino, Yoshiyuki Kagawa
Keywords
Related Articles
- EP ID EP579420
- DOI -
- Views 58
- Downloads 0
FORMULATION OF CURCUMINOID LOADED SOLID LIPID NANOPARTICLES IN ORDER TO IMPROVE ORAL BIOAVAILABILITY
Objective: Solid lipid nanoparticles (SLNs) of Curcuminoids were formulated and characterized in order to improve poor oral bioavailability of Curcumin. In vivo pharmacokinetics study in rats was conducted to demonstrate...
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPTLC METHOD FOR SIMULTANEOUS DETERMINATION OF LINAGLIPTIN AND METFORMIN
Objective: A simple, precise, and accurate stability indicating high-performance thin-layer chromatography (HPTLC) method was developed and validated for simultaneous estimation of linagliptin and metformin active pharma...
ANTIMICROBIAL PROPERTIES OF LEPTADENIA HASTATA (PERS) DECNE LEAVES EXTRACT
Objective: This study was carried out with an objective to investigate the antibacterial potential of five leaf extract of Leptadenia hastata plant on some bacteria.Methods: Leptadenia hastata extracts were evaluated for...
XANTHINE OXIDASE INHIBITORY AND ANTIHYPERURICEMIC ACTIVITIES OF ANREDERA CORDIFOLIA (TEN) STEENIS, SONCHUS ARVENSIS L, AND ITS COMBINATION
Objective: The objective of this research was to evaluate the xanthine oxidase (XO) inhibitory activity and the ability to reduce serum uric acid levels of 70% ethanol extracts of Anredera cordifolia (ACE) and Sonchus ar...
SELF-MEDICATION AMONG ADULT POPULATION IN SELANGOR, MALAYSIA
Objective: Self-medication is a common practice and an important health issue worldwide. The aim of this study was to determine the percentage of self-medication practice, patterns of use, self-medication attitudes, and...