Influence of moderate physical training on the GH/IGF-1 axis in diabetic rats
Journal Title: Biology of Sport - Year 2006, Vol 23, Issue 3
Abstract
The influence of moderate physical training on serum growth hormone (GH), insulin-like growth factor –1 (IGF-1) and binding protein ( IGFBP-3) in experimental diabetic rats was investigated. Male Wistar rats were divided into 4 groups, sedentary control (SC), trained control (TC), sedentary diabetic (SD) and trained diabetic (TD). Experimental diabetes was induced of Alloxan (35mg/b.w.) The training program consisted by swimming 5 days/week, 1 h/day, supporting a load of 2.5% b.w., during 6 weeks. Then, the rats were sacrificed and blood was collected for determinations of serum glucose, insulin, GH, IGF-1 and IGFBP-3. Samples of liver were used to evaluate glycogen, protein and DNA contents. The results were analyzed by ANOVA, and Bonferroni test and the significance level was set at 2.5%. Diabetes decreased serum GH, IGF-1, IGFBP-3 and liver glycogen stores in SD group. Physical training promoted increase in serum IGF-1 in both TC and TD groups (SC=82±15; TC=103±13; SD=77±16; TD=112± 29 ng/ml) and liver glycogen store in TD group when compared to SD (SC=5.2±1.2; TC= 6.2±1; SD=2±0.5; TD=5±1.8 mg/100mg). Therefore, physical training contributes to the increase in liver glycogen content and to rise of insulin-like growth factor level in diabetic rats. It was concluded that moderate physical training promotes important adaptations related to GH-IGF-1 axis in diabetic organisms.
Authors and Affiliations
RJ Gomes, FH Caetano, MAR Mello, E Luciano
Keywords
Related Articles
- EP ID EP58885
- DOI -
- Views 87
- Downloads 0
Effects of brief maximal exercise on interleukin-6 and tumor necrosis factor-alpha
Acute bouts of prolonged strenuous exercise are often associated with immune modulation and an increased risk of infection. However, few studies have examined immunological responses to brief maximal exercise. We investi...
Moral attitudes towards doping – what do athletes on the verge of maturity value?
The aim of the present study was twofold: a) to verify the previously detected regularities in a group of subjects larger than the one employed in a pilot study, and b) to define the internal structure of the hierarchy o...
MONITORING TRAINING LOADS, STRESS, IMMUNE-ENDOCRINE RESPONSES AND PERFORMANCE IN TENNIS PLAYERS
The study aim was to investigate the effect of a periodised pre-season training plan on internal training load and subsequent stress tolerance, immune-endocrine responses and physical performance in tennis players. Well-...
MAXIMUM NUMBER OF REPETITIONS, TOTAL WEIGHT LIFTED AND NEUROMUSCULAR FATIGUE IN INDIVIDUALS WITH DIFFERENT TRAINING BACKGROUNDS
The aim of this study was to evaluate the performance, as well as neuromuscular activity, in a strength task in subjects with different training backgrounds. Participants (n = 26) were divided into three groups according...
Plasma leptin concentrations in physically active men and women in relation to fat mass, fat free mass and selected biochemical variables
The plasma leptin concentration depends on many factors with a substantial role played by physical activity. The aim of this study was the evaluation of the effects of body fat and fat free mass as well circulating gluco...