Influence of propofol on oxidative-antioxidative system parameters in peripheral organs of rats with Parkinson disease
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2015, Vol 69, Issue 0
Abstract
Propofol (2,6-diisopropylphenol) is a popular anaesthetic agent with antioxidant properties. The aim of the study was to assess the oxidant-antioxidant system parameters of particular organs (liver, kidney, heart, and lungs) in response to propofol administered to rats with Parkinson’s disease and to healthy ones.The experiment was performed using 32 Wistar rats divided into four groups (8 rats each). The groups were as follows: 1 control, 2 Parkinson’s disease, 3 control with propofol, 4 Parkinson’s disease with propofol. Propofol was administered at a dose of 60 mg/kg body weight/IP, 60 minutes before decapitation. Animals were sacrificed and livers, kidneys, hearts and lungs were obtained for further biochemical analyses. The concentration of malondialdehyde (MDA), glutathione reductase (GR) activity, glutathione peroxidase (GPx) activity, glutathione S-transferase (GST) activity and catalase (CAT) activity were determined.In group 4 compared to group 2 there was observed a significant decrease in the MDA level in liver (71%), kidneys (51%) and heart (12%), increased GR activity in lungs (48%) and heart (34%), and increased CAT activity in liver (104%). In group 3 compared to group 1 there was a significant decrease in MDA level in kidneys (67%) and lungs (14%) and increased GR activity in heart (31%), liver (29%) and lungs (21%).Propofol can prevent or reduce damage caused by reactive oxygen species (ROS) by stimulating activity of antioxidative enzymes and inhibiting lipid peroxidation. Additionally, the response of tissues to administered propofol is different in Parkinson’s disease and in healthy individuals.
Authors and Affiliations
Ewa Romuk, Wioletta Szczurek, Przemysław Nowak, Iga Kwiecień, Dominika Stolecka
Keywords
Related Articles
- EP ID EP67701
- DOI -
- Views 145
- Downloads 0
Przydatność oznaczania stężenia prokalcytoniny w porównaniu ze stężeniem białka C-reaktywnego oraz ilością białych krwinek we krwi noworodków w monitorowaniu leczenia uogólnionych zakażeń szpitalnych
Ektopia skrzyżowna nerki: czy jest to problem diagnostyczny?
Skrzyżowana ektopia nerki (C-RE) jest rzadką wadą rozwojową polegającą na przemieszczeniu nerki na stronę przeciwną, przy czym moczowód nerki ektopicznej przecina linię pośrodkową ciała i uchodzi do pęcherza moczowego...
Rola hepcydyny w metabolizmie żelaza w przebiegu nieswoistych zapaleń jelit
Hepcydyna to 25-aminokwasowy peptyd syntetyzowany głównie w hepatocytach, który odgrywa zasadniczą rolę w regulacji ogólnoustrojowej gospodarki żelazem. W odpowiedzi na stan zapalny, hepcydyna działa przez degradację fer...
Związek wybranych polimorfizmów genów z metabolizmem statyn, ryzykiem udaru niedokrwiennego mózgu i chorób sercowo-naczyniowych
Rho-kinase inhibitor reduces hypersensitivity to ANG II in human mesenteric arteries retrieved and conserved under the same conditions as transplanted organs
Rho-kinase and GTP-ase Rho are important regulators of vascular tone and blood pressure. The aim of this study was to investigate the role of Rho-kinase in artery reactions induced by angiotensin II (ANG II) and the effe...