Influence of recovery treatment based on the haloaerosoltherapy upon non-specific defense of children with recurrent respiratory diseases
Journal Title: Астма и Аллергия - Year 2018, Vol 1, Issue 4
Abstract
Abstract Objective was to study the influence of different treatment complexes based on haloaerosoltherapy with increased concentration of rock-salt aerosol upon non-specific defense at children with recurrent respiratory diseases . Materials and methods. 74 patients with recurrent respiratory diseases and 12 healthy children aged 6-11 years were examined. The phagocytic activity of neutrophils and monocytes was studied. Phagocytic reserve of neutrophils was evaluated using the nitroblue tetrazolium (NBT-test). The levels of lysosome cationic proteins and myeloperoxidase in neutrophils were determined, percentage of positive cells was taken into account and cytochemical coefficients were calculated. The treatment was performed according to two treatment complexes. Treatment complex-1 included 18 sessions of haloaerosoltherapy with haloaerosol concentration 40-35 mg/m3 . Treatment complex-2 provided 13 procedures of haloaerosoltherapy and additional prescription of singlet-oxygen therapy in a form of foam. Results. Decrease in the absorbing properties of neutrophils and monocytes was registered in children with recurrent respiratory diseases, which is confirmed by lowering of relevant indices in comparison with control group (p<0,001). In addition, significant decrease in PhR and inhibition of oxygen-dependent mechanisms of intracellular bactericidity of neutrophils with minor deviations of their non-oxygen-dependent mechanisms was revealed. Usage of treatment complexes on the basis of haloaerosoltherapy resulted in the improvement of the functional characteristics of neutrophils and monocytes, without significant difference between treatment complexes. Significant increase of the spontaneous and induced NST-test indexes, without a significant increase in the reserve of neutrophils was registered. A valuable elevation of the levels of lysosome cationic proteins, myeloperoxidase and normalization of the corresponding coefficients was noted, which indicated the improvement of intracellular bactericidal properties. Conclusions. Usage of haloaerosoltherapy on the period of recovery treatment at children with recurrent respiratory diseases leads to improvement of absorption properties of neutrophils and monocytes, with increasing bactericidal features of neutrophils which testifies the improvement of nonspecific defense. Reducing the course of haloaerosoltherapy is possible in case of additional prescription of other treatment factor, such as singlet-oxygen therapy
Authors and Affiliations
O. I. Lemko, S. V. Lukashchuk, M. I. Popadinets
Keywords
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- EP ID EP441714
- DOI 10.31655/2307-3373-2018-4-7-11
- Views 144
- Downloads 0
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